PSMD7

GENE INFORMATION

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Gene name

PSMD7 (HGNC Symbol)

Synonyms

MOV34, P40, Rpn8, S12

Description

Proteasome (prosome, macropain) 26S subunit, non-ATPase, 7 (HGNC Symbol)

Entrez gene summary

The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a non-ATPase subunit of the 19S regulator. A pseudogene has been identified on chromosome 17. [provided by RefSeq, Jul 2008]

Chromosome

16

Cytoband

q23.1

Chromosome location (bp)

74296775 - 74306288

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000103035 (version 78.38)

Entrez gene

5713

UniProt

P51665 (UniProt - Evidence at protein level)

neXtProt

NX_P51665

Antibodypedia

PSMD7 antibodies
 

PROTEIN VIEW

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PSMD7-001
 
PSMD7-004
 
PSMD7-005
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PSMD7-001 ENSP00000219313
ENST00000219313
P51665
Show all »
Show » Show » 324 37 No 0
PSMD7-004 ENSP00000457244
ENST00000567958
H3BTM8
Show all »
Show » Show » 198 22.3 No 0
PSMD7-005 ENSP00000454999
ENST00000568615
H3BNT7
Show all »
Show » Show » 177 20.1 No 0