MMP15

GENE INFORMATION

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Gene name

MMP15 (HGNC Symbol)

Synonyms

MT2-MMP, MTMMP2, SMCP-2

Description

Matrix metallopeptidase 15 (membrane-inserted) (HGNC Symbol)

Entrez gene summary

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily; each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. [provided by RefSeq, Jul 2008]

Chromosome

16

Cytoband

q21

Chromosome location (bp)

58025566 - 58046901

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000102996 (version 78.38)

Entrez gene

4324

UniProt

P51511 (UniProt - Evidence at protein level)

neXtProt

NX_P51511

Antibodypedia

MMP15 antibodies
 

PROTEIN VIEW

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MMP15-001
 
MMP15-002
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

MMP15-001 ENSP00000219271
ENST00000219271
P51511
Show all »
Show » Show » 669 75.8 Yes 1
MMP15-002 ENSP00000457084
ENST00000570065
Show » Show » 97 10.8 No 0