MYOM1

GENE INFORMATION

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Gene name

MYOM1

Synonyms

Description

Myomesin 1 (HGNC Symbol)

Entrez gene summary

The giant protein titin, together with its associated proteins, interconnects the major structure of sarcomeres, the M bands and Z discs. The C-terminal end of the titin string extends into the M line, where it binds tightly to M-band constituents of apparent molecular masses of 190 kD (myomesin 1) and 165 kD (myomesin 2). This protein, myomesin 1, like myomesin 2, titin, and other myofibrillar proteins contains structural modules with strong homology to either fibronectin type III (motif I) or immunoglobulin C2 (motif II) domains. Myomesin 1 and myomesin 2 each have a unique N-terminal region followed by 12 modules of motif I or motif II, in the arrangement II-II-I-I-I-I-I-II-II-II-II-II. The two proteins share 50% sequence identity in this repeat-containing region. The head structure formed by these 2 proteins on one end of the titin string extends into the center of the M band. The integrating structure of the sarcomere arises from muscle-specific members of the superfamily of immunoglobulin-like proteins. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

Chromosome

18

Cytoband

p11.31

Chromosome location (bp)

3066807 - 3220108

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000101605 (version 78.38)

Entrez gene

8736

UniProt

P52179 (UniProt - Evidence at protein level)

neXtProt

NX_P52179

Antibodypedia

MYOM1 antibodies
 

PROTEIN VIEW

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MYOM1-001
 
MYOM1-003
 
MYOM1-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

MYOM1-001 ENSP00000348821
ENST00000356443
P52179
Show all »
Show » Show » 1685 187.6 No 0
MYOM1-003 ENSP00000261606
ENST00000261606
P52179
Show all »
Show » Show » 1589 177.7 No 0
MYOM1-201 ENSP00000383413
ENST00000400569
Show » Show » 1452 162.3 No 0