WFDC2

GENERAL INFORMATION

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Gene name

WFDC2

Gene description

WAP four-disulfide core domain 2

Protein class

Cancer-related genes
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

Intracellular,Secreted

Number of transcripts

4
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Tissue enhanced (fallopian tube, salivary gland)
GTEx:Tissue enhanced (cervix, uterine, kidney, salivary gland)

Protein evidence

Evidence at protein level

Protein localization

Cytoplasmic expression in several tissues, most abundant in male reproductive organs.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining mainly consistent with RNA expression data. Secreted protein, tissue location of RNA and protein might differ and correlation is complex.

Data reliability

Supportive based on 1 antibody.
HPA042302
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Salivary gland

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Tissue enhanced (fallopian tube, salivary gland)

Organ

Expression

GTEx dataset
RNA tissue category:  Tissue enhanced (cervix, uterine, kidney, salivary gland)

Organ

Expression



GENE INFORMATION

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Gene name

WFDC2 (HGNC Symbol)

Synonyms

dJ461P17.6, EDDM4, HE4, WAP5

Description

WAP four-disulfide core domain 2 (HGNC Symbol)

Entrez gene summary

This gene encodes a protein that is a member of the WFDC domain family. The WFDC domain, or WAP Signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor in many family members. This gene is expressed in pulmonary epithelial cells, and was also found to be expressed in some ovarian cancers. The encoded protein is a small secretory protein, which may be involved in sperm maturation. [provided by RefSeq, Jul 2008]

Chromosome

20

Cytoband

q13.12

Chromosome location (bp)

45469706 - 45481532

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000101443 (version 78.38)

Entrez gene

10406

UniProt

Q14508 (UniProt - Evidence at protein level)

neXtProt

NX_Q14508

Antibodypedia

WFDC2 antibodies


PROTEIN BROWSER

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ENST00000217425
 
ENST00000339946
 
ENST00000342873
 
ENST00000372676
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

WFDC2-002 ENSP00000361761
ENST00000372676
Q14508
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Show » Show » 124 13 Yes 0
WFDC2-003 ENSP00000217425
ENST00000217425
Q14508
Show all »
Show » Show » 102 11 Yes 0
WFDC2-005 ENSP00000340215
ENST00000339946
Q14508
Show all »
Show » Show » 76 8.1 Yes 0
WFDC2-006 ENSP00000342890
ENST00000342873
Q14508
Show all »
Show » Show » 73 8.1 No 0