ASIP

GENE INFORMATION

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Gene name

ASIP (HGNC Symbol)

Synonyms

AGTIL, ASP

Description

Agouti signaling protein (HGNC Symbol)

Entrez gene summary

In mice, the agouti gene encodes a paracrine signaling molecule that causes hair follicle melanocytes to synthesize pheomelanin, a yellow pigment, instead of the black or brown pigment, eumelanin. Pleiotropic effects of constitutive expression of the mouse gene include adult-onset obesity, increased tumor susceptibility, and premature infertility. This gene is highly similar to the mouse gene and encodes a secreted protein that may (1) affect the quality of hair pigmentation, (2) act as a pharmacological antagonist of alpha-melanocyte-stimulating hormone, (3) play a role in neuroendocrine aspects of melanocortin action, and (4) have a functional role in regulating lipid metabolism in adipocytes. [provided by RefSeq, Jul 2008]

Chromosome

20

Cytoband

q11.22

Chromosome location (bp)

34194569 - 34269344

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000101440 (version 78.38)

Entrez gene

434

UniProt

P42127 (UniProt - Evidence at protein level)

neXtProt

NX_P42127

Antibodypedia

ASIP antibodies
 

PROTEIN VIEW

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ASIP-001
 
ASIP-002
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ASIP-001 ENSP00000364092
ENST00000374954
P42127
Show all »
Show » Show » 132 14.5 Yes 0
ASIP-002 ENSP00000454804
ENST00000568305
P42127
Show all »
Show » Show » 132 14.5 Yes 0