E2F1

GENERAL INFORMATION

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Gene name

E2F1

Gene description

E2F transcription factor 1

Protein class

Cancer-related genes
Plasma proteins
Predicted intracellular proteins
Transcription factors

Predicted localization

Intracellular

Number of transcripts

2
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Tissue enhanced (bone marrow)
GTEx:Tissue enhanced (testis)

Protein evidence

Evidence at protein level

Protein localization

General nuclear expression.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Supportive based on 3 antibodies.
HPA008003 , CAB000329 , CAB019308
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Bone marrow

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Tissue enhanced (bone marrow)

Organ

Expression

GTEx dataset
RNA tissue category:  Tissue enhanced (testis)

Organ

Expression



GENE INFORMATION

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Gene name

E2F1 (HGNC Symbol)

Synonyms

RBBP3, RBP3

Description

E2F transcription factor 1 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F2 and E2F3, have an additional cyclin binding domain. This protein binds preferentially to retinoblastoma protein pRB in a cell-cycle dependent manner. It can mediate both cell proliferation and p53-dependent/independent apoptosis. [provided by RefSeq, Jul 2008]

Chromosome

20

Cytoband

q11.22

Chromosome location (bp)

33675487 - 33686404

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000101412 (version 78.38)

Entrez gene

1869

UniProt

Q01094 (UniProt - Evidence at protein level)

neXtProt

NX_Q01094

Antibodypedia

E2F1 antibodies


PROTEIN BROWSER

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ENST00000343380
 
ENST00000622594
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

E2F1-001 ENSP00000345571
ENST00000343380
Q01094
Show all »
Show » Show » 437 46.9 No 0
E2F1-201 ENSP00000480001
ENST00000622594
Q01094
Show all »
Show » Show » 437 46.9 No 0