OXT

GENE INFORMATION

? »

Gene name

OXT (HGNC Symbol)

Synonyms

OT, OT-NPI, OXT-NPI

Description

Oxytocin/neurophysin I prepropeptide (HGNC Symbol)

Entrez gene summary

This gene encodes a precursor protein that is processed to produce oxytocin and neurophysin I. Oxytocin is a posterior pituitary hormone which is synthesized as an inactive precursor in the hypothalamus along with its carrier protein neurophysin I. Together with neurophysin, it is packaged into neurosecretory vesicles and transported axonally to the nerve endings in the neurohypophysis, where it is either stored or secreted into the bloodstream. The precursor seems to be activated while it is being transported along the axon to the posterior pituitary. This hormone contracts smooth muscle during parturition and lactation. It is also involved in cognition, tolerance, adaptation and complex sexual and maternal behaviour, as well as in the regulation of water excretion and cardiovascular functions. [provided by RefSeq, Dec 2013]

Chromosome

20

Cytoband

p13

Chromosome location (bp)

3071620 - 3072517

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000101405 (version 78.38)

Entrez gene

5020

UniProt

P01178 (UniProt - Evidence at protein level)

neXtProt

NX_P01178

Antibodypedia

OXT antibodies
 

PROTEIN VIEW

? »
 
 
 
OXT-001
 
 
 
 
 

PROTEIN INFORMATION

? »

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

OXT-001 ENSP00000217386
ENST00000217386
P01178
Show all »
Show » Show » 125 12.7 Yes 0