IDH3B

GENE INFORMATION

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Gene name

IDH3B (HGNC Symbol)

Synonyms

RP46

Description

Isocitrate dehydrogenase 3 (NAD+) beta (HGNC Symbol)

Entrez gene summary

Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. NAD(+)-dependent isocitrate dehydrogenases catalyze the allosterically regulated rate-limiting step of the tricarboxylic acid cycle. Each isozyme is a heterotetramer that is composed of two alpha subunits, one beta subunit, and one gamma subunit. The protein encoded by this gene is the beta subunit of one isozyme of NAD(+)-dependent isocitrate dehydrogenase. Three alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

Chromosome

20

Cytoband

p13

Chromosome location (bp)

2658395 - 2664219

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000101365 (version 78.38)

Entrez gene

3420

UniProt

O43837 (UniProt - Evidence at protein level)

neXtProt

NX_O43837

Antibodypedia

IDH3B antibodies
 

PROTEIN VIEW

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IDH3B-001
 
IDH3B-010
 
IDH3B-011
 
IDH3B-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

IDH3B-001 ENSP00000482773
ENST00000474315
Q9UIC5
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Show » Show » 387 42.4 No 0
IDH3B-010 ENSP00000370232
ENST00000380851
O43837
Show all »
Show » Show » 383 41.9 No 0
IDH3B-011 ENSP00000370223
ENST00000380843
O43837
Show all »
Show » Show » 385 42.2 No 0
IDH3B-201 ENSP00000484922
ENST00000613370
B4DU38
Show all »
Show » Show » 376 41.2 No 0