NFKBIA

GENE INFORMATION

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Gene name

NFKBIA (HGNC Symbol)

Synonyms

IkappaBalpha, IKBA, MAD-3, NFKBI

Description

Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the NF-kappa-B inhibitor family, which contain multiple ankrin repeat domains. The encoded protein interacts with REL dimers to inhibit NF-kappa-B/REL complexes which are involved in inflammatory responses. The encoded protein moves between the cytoplasm and the nucleus via a nuclear localization signal and CRM1-mediated nuclear export. Mutations in this gene have been found in ectodermal dysplasia anhidrotic with T-cell immunodeficiency autosomal dominant disease. [provided by RefSeq, Aug 2011]

Chromosome

14

Cytoband

q13.2

Chromosome location (bp)

35401511 - 35404749

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000100906 (version 78.38)

Entrez gene

4792

UniProt

P25963 (UniProt - Evidence at protein level)

neXtProt

NX_P25963

Antibodypedia

NFKBIA antibodies
 

PROTEIN VIEW

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NFKBIA-001
 
NFKBIA-002
 
NFKBIA-004
 
NFKBIA-011
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

NFKBIA-001 ENSP00000216797
ENST00000216797
P25963
Show all »
Show » Show » 317 35.6 No 0
NFKBIA-002 ENSP00000451257
ENST00000557140
G3V3I4
Show all »
Show » Show » 274 30.9 No 0
NFKBIA-004 ENSP00000450514
ENST00000557389
G3V286
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Show » Show » 227 25 No 0
NFKBIA-011 ENSP00000451281
ENST00000553342
G3V3K1
Show all »
Show » 69 8.1 No 0