PSMA6

GENERAL INFORMATION

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Gene name

PSMA6

Gene description

Proteasome (prosome, macropain) subunit, alpha type, 6

Protein class

Enzymes
Plasma proteins
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

7
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

General nuclear and cytoplasmic expression.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining mainly consistent with RNA expression data. Pending external verification.

Data reliability

Uncertain based on 1 antibody.
HPA003049
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

PSMA6 (HGNC Symbol)

Synonyms

IOTA, MGC22756, MGC2333, MGC23846, p27K, PROS27

Description

Proteasome (prosome, macropain) subunit, alpha type, 6 (HGNC Symbol)

Entrez gene summary

The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. Multiple transcript variants encoding several different isoforms have been found for this gene. A pseudogene has been identified on the Y chromosome. [provided by RefSeq, Aug 2013]

Chromosome

14

Cytoband

q13.2

Chromosome location (bp)

35278633 - 35317493

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000100902 (version 78.38)

Entrez gene

5687

UniProt

P60900 (UniProt - Evidence at protein level)

neXtProt

NX_P60900

Antibodypedia

PSMA6 antibodies


PROTEIN BROWSER

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ENST00000261479
 
ENST00000540871
 
ENST00000553809
 
ENST00000555764
 
ENST00000556221
 
ENST00000556506
 
ENST00000622405
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PSMA6-001 ENSP00000261479
ENST00000261479
P60900
Show all »
Show » Show » 246 27.4 No 0
PSMA6-002 ENSP00000444844
ENST00000540871
P60900
Show all »
Show » Show » 227 25.3 No 0
PSMA6-004 ENSP00000452566
ENST00000555764
P60900
Show all »
Show » Show » 167 18.8 No 0
PSMA6-010 ENSP00000452603
ENST00000553809
G3V5Z7
Show all »
Show » Show » 252 28.1 No 0
PSMA6-012 ENSP00000451171
ENST00000556221
Show » Show » 85 9.2 No 0
PSMA6-013 ENSP00000450528
ENST00000556506
G3V295
Show all »
Show » Show » 203 22.8 No 0
PSMA6-201 ENSP00000479620
ENST00000622405
P60900
Show all »
Show » Show » 167 18.8 No 0