TCL1A

GENE INFORMATION

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Gene name

TCL1A (HGNC Symbol)

Synonyms

TCL1

Description

T-cell leukemia/lymphoma 1A (HGNC Symbol)

Entrez gene summary

Overexpression of the TCL1 gene in humans has been implicated in the development of mature T cell leukemia, in which chromosomal rearrangements bring the TCL1 gene in close proximity to the T-cell antigen receptor (TCR)-alpha (MIM 186880) or TCR-beta (MIM 186930) regulatory elements (summarized by Virgilio et al., 1998 [PubMed 9520462]). In normal T cells TCL1 is expressed in CD4-/CD8- cells, but not in cells at later stages of differentiation. TCL1 functions as a coactivator of the cell survival kinase AKT (MIM 164730) (Laine et al., 2000 [PubMed 10983986]).[supplied by OMIM, Jul 2010]

Chromosome

14

Cytoband

q32.13

Chromosome location (bp)

95709967 - 95714196

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000100721 (version 78.38)

Entrez gene

8115

UniProt

P56279 (UniProt - Evidence at protein level)

neXtProt

NX_P56279

Antibodypedia

TCL1A antibodies
 

PROTEIN VIEW

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TCL1A-001
 
TCL1A-002
 
TCL1A-005
 
TCL1A-007
 
TCL1A-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

TCL1A-001 ENSP00000451506
ENST00000554012
P56279
Show all »
Show » Show » 114 13.5 No 0
TCL1A-002 ENSP00000450496
ENST00000555202
P56279
Show all »
Show » Show » 114 13.5 No 0
TCL1A-005 ENSP00000450701
ENST00000556450
P56279
Show all »
Show » Show » 114 13.5 No 0
TCL1A-007 ENSP00000452028
ENST00000557043
Show » 89 10.1 No 0
TCL1A-201 ENSP00000385036
ENST00000402399
P56279
Show all »
Show » Show » 114 13.5 No 0