HIF1A

GENERAL INFORMATION

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Gene name

HIF1A

Gene description

Hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)

Protein class

Cancer-related genes
Plasma proteins
Predicted intracellular proteins
Transcription factors

Predicted localization

Intracellular

Number of transcripts

5
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Mainly nuclear expression but cytoplasmic as well in some tissues. High expression levels in bone marrow, gallbladder and exocrine pancreas.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Supportive based on 2 antibodies.
HPA001275 , CAB017442
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Bone marrow

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

HIF1A (HGNC Symbol)

Synonyms

bHLHe78, HIF-1alpha, HIF1, MOP1, PASD8

Description

Hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) (HGNC Symbol)

Entrez gene summary

This gene encodes the alpha subunit of transcription factor hypoxia-inducible factor-1 (HIF-1), which is a heterodimer composed of an alpha and a beta subunit. HIF-1 functions as a master regulator of cellular and systemic homeostatic response to hypoxia by activating transcription of many genes, including those involved in energy metabolism, angiogenesis, apoptosis, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. HIF-1 thus plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2011]

Chromosome

14

Cytoband

q23.2

Chromosome location (bp)

61695513 - 61748259

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000100644 (version 78.38)

Entrez gene

3091

UniProt

Q16665 (UniProt - Evidence at protein level)

neXtProt

NX_Q16665

Antibodypedia

HIF1A antibodies


PROTEIN BROWSER

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ENST00000323441
 
ENST00000337138
 
ENST00000394997
 
ENST00000539097
 
ENST00000557538
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

HIF1A-001 ENSP00000338018
ENST00000337138
Q16665
Show all »
Show » Show » 826 92.7 No 0
HIF1A-002 ENSP00000323326
ENST00000323441
Q16665
Show all »
Show » Show » 735 82.7 No 0
HIF1A-003 ENSP00000378446
ENST00000394997
A8MYV6
Show all »
Show » Show » 827 92.8 No 0
HIF1A-004 ENSP00000451696
ENST00000557538
F8W9L0
Show all »
Show » Show » 767 86.1 No 0
HIF1A-201 ENSP00000437955
ENST00000539097
Q16665
Show all »
Show » Show » 850 95.6 No 0