IL2RB

GENE INFORMATION

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Gene name

IL2RB (HGNC Symbol)

Synonyms

CD122, IL15RB

Description

Interleukin 2 receptor, beta (HGNC Symbol)

Entrez gene summary

The interleukin 2 receptor, which is involved in T cell-mediated immune responses, is present in 3 forms with respect to ability to bind interleukin 2. The low affinity form is a monomer of the alpha subunit and is not involved in signal transduction. The intermediate affinity form consists of an alpha/beta subunit heterodimer, while the high affinity form consists of an alpha/beta/gamma subunit heterotrimer. Both the intermediate and high affinity forms of the receptor are involved in receptor-mediated endocytosis and transduction of mitogenic signals from interleukin 2. The protein encoded by this gene represents the beta subunit and is a type I membrane protein. [provided by RefSeq, Jul 2008]

Chromosome

22

Cytoband

q12.3

Chromosome location (bp)

37125838 - 37175054

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000100385 (version 78.38)

Entrez gene

3560

UniProt

P14784 (UniProt - Evidence at protein level)

neXtProt

NX_P14784

Antibodypedia

IL2RB antibodies
 

PROTEIN VIEW

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IL2RB-001
 
IL2RB-005
 
IL2RB-006
 
IL2RB-008
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

IL2RB-001 ENSP00000216223
ENST00000216223
P14784
Show all »
Show » Show » 551 61.1 Yes 1
IL2RB-005 ENSP00000402685
ENST00000429622
B0QYC1
Show all »
Show » Show » 146 16.4 Yes 0
IL2RB-006 ENSP00000403731
ENST00000453962
B0QYC0
Show all »
Show » Show » 188 21.4 Yes 0
IL2RB-008 ENSP00000401020
ENST00000445595
B0QYC2
Show all »
Show » Show » 88 9.8 Yes 0