RBFOX2

GENERAL INFORMATION

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Gene name

RBFOX2

Gene description

RNA binding protein, fox-1 homolog (C. elegans) 2

Protein class

Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

12
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Mixed
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

General nuclear and cytoplasmic expression.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Data reliability

Uncertain based on 1 antibody.
HPA006240
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Smooth muscle

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Mixed

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

RBFOX2 (HGNC Symbol)

Synonyms

FOX-2, HNRBP2, HRNBP2, RBM9

Description

RNA binding protein, fox-1 homolog (C. elegans) 2 (HGNC Symbol)

Entrez gene summary

This gene is one of several human genes similar to the C. elegans gene Fox-1. This gene encodes an RNA binding protein that is thought to be a key regulator of alternative exon splicing in the nervous system and other cell types. The protein binds to a conserved UGCAUG element found downstream of many alternatively spliced exons and promotes inclusion of the alternative exon in mature transcripts. The protein also interacts with the estrogen receptor 1 transcription factor and regulates estrogen receptor 1 transcriptional activity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

22

Cytoband

q12.3

Chromosome location (bp)

35738736 - 36028425

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000100320 (version 78.38)

Entrez gene

23543

UniProt

O43251 (UniProt - Evidence at protein level)

neXtProt

NX_O43251

Antibodypedia

RBFOX2 antibodies


PROTEIN BROWSER

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ENST00000262829
 
ENST00000359369
 
ENST00000397303
 
ENST00000397305
 
ENST00000405409
 
ENST00000408983
 
ENST00000414461
 
ENST00000416721
 
ENST00000438146
 
ENST00000449924
 
ENST00000473487
 
ENST00000495377
 
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PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

RBFOX2-001 ENSP00000384944
ENST00000405409
O43251
Show all »
Show » Show » 367 39.5 No 0
RBFOX2-002 ENSP00000262829
ENST00000262829
O43251
Show all »
Show » Show » 358 37.9 No 0
RBFOX2-003 ENSP00000391670
ENST00000449924
O43251
Show all »
Show » Show » 380 40.4 No 0
RBFOX2-004 ENSP00000474464
ENST00000495377
Show » Show » 230 23.8 No 0
RBFOX2-005 ENSP00000413035
ENST00000438146
O43251
Show all »
Show » Show » 451 47.3 No 0
RBFOX2-006 ENSP00000352328
ENST00000359369
B0QYY4
Show all »
Show » Show » 370 39.9 No 0
RBFOX2-008 ENSP00000405651
ENST00000416721
O43251
Show all »
Show » Show » 376 40 No 0
RBFOX2-009 ENSP00000380470
ENST00000397303
B0QYV1
Show all »
Show » Show » 357 37.9 No 0
RBFOX2-010 ENSP00000407855
ENST00000414461
O43251
Show all »
Show » Show » 370 39.8 No 0
RBFOX2-012 ENSP00000386177
ENST00000408983
B0QYY7
Show all »
Show » Show » 200 21.8 No 0
RBFOX2-013 ENSP00000380472
ENST00000397305
B0QYY6
Show all »
Show » Show » 128 14 No 0
RBFOX2-014 ENSP00000475142
ENST00000473487
S4R469
Show all »
Show » Show » 234 25.3 No 0