MCM5

GENERAL INFORMATION

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Gene name

MCM5

Gene description

Minichromosome maintenance complex component 5

Protein class

Cancer-related genes
Enzymes
Plasma proteins
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

4
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Nuclear expression mainly in bone marrow poietic cells, lymphocytes in tonsil and trophoblastic cells in placenta. The protein is also expressed in a few other cell types but at lower intensity.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Supportive based on 2 antibodies.
HPA000845 , CAB000101
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

MCM5 (HGNC Symbol)

Synonyms

CDC46

Description

Minichromosome maintenance complex component 5 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is structurally very similar to the CDC46 protein from S. cerevisiae, a protein involved in the initiation of DNA replication. The encoded protein is a member of the MCM family of chromatin-binding proteins and can interact with at least two other members of this family. The encoded protein is upregulated in the transition from the G0 to G1/S phase of the cell cycle and may actively participate in cell cycle regulation. [provided by RefSeq, Jul 2008]

Chromosome

22

Cytoband

q12.3

Chromosome location (bp)

35400063 - 35425430

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000100297 (version 78.38)

Entrez gene

4174

UniProt

P33992 (UniProt - Evidence at protein level)

neXtProt

NX_P33992

Antibodypedia

MCM5 antibodies


PROTEIN BROWSER

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ENST00000216122
 
ENST00000382011
 
ENST00000416905
 
ENST00000444778
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

MCM5-001 ENSP00000216122
ENST00000216122
P33992
Show all »
Show » Show » 734 82.3 No 0
MCM5-002 ENSP00000371441
ENST00000382011
B1AHB1
Show all »
Show » Show » 691 77.6 No 0
MCM5-008 ENSP00000393977
ENST00000416905
B1AHA9
Show all »
Show » Show » 231 25.9 No 0
MCM5-011 ENSP00000408705
ENST00000444778
B1AHB2
Show all »
Show » Show » 150 16.8 No 0