XBP1

GENE INFORMATION

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Gene name

XBP1 (HGNC Symbol)

Synonyms

XBP2

Description

X-box binding protein 1 (HGNC Symbol)

Entrez gene summary

This gene encodes a transcription factor that regulates MHC class II genes by binding to a promoter element referred to as an X box. This gene product is a bZIP protein, which was also identified as a cellular transcription factor that binds to an enhancer in the promoter of the T cell leukemia virus type 1 promoter. It may increase expression of viral proteins by acting as the DNA binding partner of a viral transactivator. It has been found that upon accumulation of unfolded proteins in the endoplasmic reticulum (ER), the mRNA of this gene is processed to an active form by an unconventional splicing mechanism that is mediated by the endonuclease inositol-requiring enzyme 1 (IRE1). The resulting loss of 26 nt from the spliced mRNA causes a frame-shift and an isoform XBP1(S), which is the functionally active transcription factor. The isoform encoded by the unspliced mRNA, XBP1(U), is constitutively expressed, and thought to function as a negative feedback regulator of XBP1(S), which shuts off transcription of target genes during the recovery phase of ER stress. A pseudogene of XBP1 has been identified and localized to chromosome 5. [provided by RefSeq, Jul 2008]

Chromosome

22

Cytoband

q12.1

Chromosome location (bp)

28794555 - 28800597

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000100219 (version 78.38)

Entrez gene

7494

UniProt

P17861 (UniProt - Evidence at transcript level)

neXtProt

NX_P17861

Antibodypedia

XBP1 antibodies
 

PROTEIN VIEW

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XBP1-001
 
XBP1-003
 
XBP1-006
 
XBP1-007
 
XBP1-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

XBP1-001 ENSP00000216037
ENST00000216037
P17861
Show all »
Show » Show » 261 28.7 No 0
XBP1-003 ENSP00000384295
ENST00000405219
B1AHH1
Show all »
Show » Show » 211 24 No 1
XBP1-006 ENSP00000385162
ENST00000403532
B1AHH2
Show all »
Show » Show » 266 29.3 No 0
XBP1-007 ENSP00000343155
ENST00000344347
P17861
Show all »
Show » Show » 376 40.1 No 0
XBP1-201 ENSP00000481170
ENST00000611155
P17861
Show all »
Show » Show » 376 40.1 No 0