CYP2D6

GENE INFORMATION

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Gene name

CYP2D6 (HGNC Symbol)

Synonyms

CPD6, CYP2D, CYP2D7AP, CYP2D7BP, CYP2D7P2, CYP2D8P2, CYP2DL1, P450-DB1, P450C2D

Description

Cytochrome P450, family 2, subfamily D, polypeptide 6 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize as many as 25% of commonly prescribed drugs. Its substrates include antidepressants, antipsychotics, analgesics and antitussives, beta adrenergic blocking agents, antiarrythmics and antiemetics. The gene is highly polymorphic in the human population; certain alleles result in the poor metabolizer phenotype, characterized by a decreased ability to metabolize the enzyme's substrates. Some individuals with the poor metabolizer phenotype have no functional protein since they carry 2 null alleles whereas in other individuals the gene is absent. This gene can vary in copy number and individuals with the ultrarapid metabolizer phenotype can have 3 or more active copies of the gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]

Chromosome

22

Cytoband

q13.2

Chromosome location (bp)

42126499 - 42130906

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000100197 (version 78.38)

Entrez gene

1565

UniProt

P10635 (UniProt - Evidence at protein level)

neXtProt

NX_P10635

Antibodypedia

CYP2D6 antibodies
 

PROTEIN VIEW

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CYP2D6-001
 
CYP2D6-002
 
CYP2D6-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CYP2D6-001 ENSP00000353820
ENST00000360608
P10635
Show all »
Show » Show » 497 55.8 No 2
CYP2D6-002 ENSP00000351927
ENST00000359033
P10635
Show all »
Show » Show » 446 50.1 No 2
CYP2D6-201 ENSP00000374620
ENST00000389970
Show » Show » 494 55.2 No 0