GCAT

GENE INFORMATION

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Gene name

GCAT (HGNC Symbol)

Synonyms

KBL

Description

Glycine C-acetyltransferase (HGNC Symbol)

Entrez gene summary

The degradation of L-threonine to glycine consists of a two-step biochemical pathway involving the enzymes L-threonine dehydrogenase and 2-amino-3-ketobutyrate coenzyme A ligase. L-Threonine is first converted into 2-amino-3-ketobutyrate by L-threonine dehydrogenase. This gene encodes the second enzyme in this pathway, which then catalyzes the reaction between 2-amino-3-ketobutyrate and coenzyme A to form glycine and acetyl-CoA. The encoded enzyme is considered a class II pyridoxal-phosphate-dependent aminotransferase. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 14. [provided by RefSeq, Jan 2010]

Chromosome

22

Cytoband

q13.1

Chromosome location (bp)

37807905 - 37817176

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000100116 (version 78.38)

Entrez gene

23464

UniProt

O75600 (UniProt - Evidence at protein level)

neXtProt

NX_O75600

Antibodypedia

GCAT antibodies
 

PROTEIN VIEW

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GCAT-001
 
GCAT-002
 
GCAT-003
 
GCAT-004
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

GCAT-001 ENSP00000248924
ENST00000248924
O75600
Show all »
Show » Show » 419 45.3 No 0
GCAT-002 ENSP00000371110
ENST00000323205
O75600
Show all »
Show » Show » 445 48 No 0
GCAT-003 ENSP00000388151
ENST00000451984
Show » Show » 239 26.2 No 0
GCAT-004 ENSP00000406719
ENST00000445195
C9IZC9
Show all »
Show » Show » 177 19.2 No 0