UPB1

GENE INFORMATION

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Gene name

UPB1 (HGNC Symbol)

Synonyms

BUP1

Description

Ureidopropionase, beta (HGNC Symbol)

Entrez gene summary

This gene encodes a protein that belongs to the CN hydrolase family. Beta-ureidopropionase catalyzes the last step in the pyrimidine degradation pathway. The pyrimidine bases uracil and thymine are degraded via the consecutive action of dihydropyrimidine dehydrogenase (DHPDH), dihydropyrimidinase (DHP) and beta-ureidopropionase (UP) to beta-alanine and beta-aminoisobutyric acid, respectively. UP deficiencies are associated with N-carbamyl-beta-amino aciduria and may lead to abnormalities in neurological activity. [provided by RefSeq, Jul 2008]

Chromosome

22

Cytoband

q11.23

Chromosome location (bp)

24494107 - 24528390

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000100024 (version 78.38)

Entrez gene

51733

UniProt

Q9UBR1 (UniProt - Evidence at protein level)

neXtProt

NX_Q9UBR1

Antibodypedia

UPB1 antibodies
 

PROTEIN VIEW

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UPB1-001
 
UPB1-003
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

UPB1-001 ENSP00000324343
ENST00000326010
Q9UBR1
Show all »
Show » Show » 384 43.2 No 0
UPB1-003 ENSP00000372208
ENST00000382760
Q6AHZ8
Show all »
Show » Show » 186 20.9 No 0