SPECC1L

GENERAL INFORMATION

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Gene name

SPECC1L

Gene description

Sperm antigen with calponin homology and coiled-coil domains 1-like

Protein class

Disease related genes
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

5
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Not detected

Protein evidence

Evidence at protein level

Protein localization

Cytoplasmic expression in several tissues.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining mainly not consistent with RNA expression data. Pending external verification.

Data reliability

Uncertain based on 1 antibody.
HPA070614
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Not detected

Organ

Expression



GENE INFORMATION

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Gene name

SPECC1L (HGNC Symbol)

Synonyms

CYTSA, KIAA0376

Description

Sperm antigen with calponin homology and coiled-coil domains 1-like (HGNC Symbol)

Entrez gene summary

This gene encodes a coiled-coil domain containing protein. The encoded protein may play a critical role in actin-cytoskeletal reorganization during facial morphogenesis. Mutations in this gene are a cause of oblique facial clefting-1. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. A read-through transcript composed of SPECC1L (sperm antigen with calponin homology and coiled-coil domains 1-like) and the downstream ADORA2A (adenosine A2a receptor) gene sequence has been identified, but it is thought to be non-coding. [provided by RefSeq, Jun 2013]

Chromosome

22

Cytoband

q11.23

Chromosome location (bp)

24270817 - 24417740

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000100014 (version 78.38)

Entrez gene

23384

UniProt

Q69YQ0 (UniProt - Evidence at protein level)

neXtProt

NX_Q69YQ0

Antibodypedia

SPECC1L antibodies


PROTEIN BROWSER

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ENST00000314328
 
ENST00000421374
 
ENST00000437398
 
ENST00000440893
 
ENST00000541492
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SPECC1L-001 ENSP00000325785
ENST00000314328
Q69YQ0
Show all »
Show » Show » 1117 124.5 No 0
SPECC1L-002 ENSP00000405671
ENST00000421374
C9JLY8
Show all »
Show » Show » 789 88.3 No 0
SPECC1L-003 ENSP00000414354
ENST00000440893
C9JLY8
Show all »
Show » 175 18.9 No 0
SPECC1L-006 ENSP00000439633
ENST00000541492
Q69YQ0
Show all »
Show » Show » 1078 120.1 No 0
SPECC1L-201 ENSP00000393363
ENST00000437398
Q69YQ0
Show all »
Show » Show » 1117 124.5 No 0