P2RX6

GENE INFORMATION

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Gene name

P2RX6 (HGNC Symbol)

Synonyms

MGC129625, P2RXL1, P2X6, P2XM

Description

Purinergic receptor P2X, ligand-gated ion channel, 6 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene belongs to the family of P2X receptors, which are ATP-gated ion channels and mediate rapid and selective permeability to cations. This gene is predominantly expressed in skeletal muscle, and regulated by p53. The encoded protein is associated with VE-cadherin at the adherens junctions of human umbilical vein endothelial cells. Alternative splicing results in multiple transcript variants. A related pseudogene, which is also located on chromosome 22, has been identified. [provided by RefSeq, Apr 2009]

Chromosome

22

Cytoband

q11.21

Chromosome location (bp)

21009808 - 21028830

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000099957 (version 78.38)

Entrez gene

9127

UniProt

O15547 (UniProt - Evidence at protein level)

neXtProt

NX_O15547

Antibodypedia

P2RX6 antibodies
 

PROTEIN VIEW

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P2RX6-001
 
P2RX6-003
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

P2RX6-001 ENSP00000416193
ENST00000413302
O15547
Show all »
Show » Show » 441 48.8 No 2
P2RX6-003 ENSP00000385309
ENST00000401443
O15547
Show all »
Show » Show » 415 45.8 No 1