DSP

GENE INFORMATION

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Gene name

DSP (HGNC Symbol)

Synonyms

DPI, DPII, KPPS2, PPKS2

Description

Desmoplakin (HGNC Symbol)

Entrez gene summary

Desmosomes are intercellular junctions that tightly link adjacent cells. Desmoplakin is an obligate component of functional desmosomes that anchors intermediate filaments to desmosomal plaques. The N-terminus of desmoplakin is required for localization to the desmosome and interacts with the N-terminal region of plakophilin 1 and plakoglobin. The C-terminus of desmoplakin binds with intermediate filaments. In the mid-region of desmoplakin, a coiled-coiled rod domain is responsible for homodimerization. Mutations in this gene are the cause of several cardiomyopathies and keratodermas as well as the autoimmune disease paraneoplastic pemphigus. [provided by RefSeq, Jul 2008]

Chromosome

6

Cytoband

p24.3

Chromosome location (bp)

7541575 - 7586717

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000096696 (version 78.38)

Entrez gene

1832

UniProt

P15924 (UniProt - Evidence at protein level)

neXtProt

NX_P15924

Antibodypedia

DSP antibodies
 

PROTEIN VIEW

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DSP-001
 
DSP-002
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

DSP-001 ENSP00000369129
ENST00000379802
P15924
Show all »
Show » Show » 2871 331.8 No 0
DSP-002 ENSP00000396591
ENST00000418664
P15924
Show all »
Show » Show » 2272 260.1 No 0