MAP3K1

GENE INFORMATION

? »

Gene name

MAP3K1 (HGNC Symbol)

Synonyms

MAPKKK1, MEKK, MEKK1

Description

Mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a serine/threonine kinase and is part of some signal transduction cascades, including the ERK and JNK kinase pathways as well as the NF-kappa-B pathway. The encoded protein is activated by autophosphorylation and requires magnesium as a cofactor in phosphorylating other proteins. This protein has E3 ligase activity conferred by a plant homeodomain (PHD) in its N-terminus and phospho-kinase activity conferred by a kinase domain in its C-terminus. [provided by RefSeq, Mar 2012]

Chromosome

5

Cytoband

q11.2

Chromosome location (bp)

56815574 - 56896152

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000095015 (version 78.38)

Entrez gene

4214

UniProt

Q13233 (UniProt - Evidence at protein level)

neXtProt

NX_Q13233

Antibodypedia

MAP3K1 antibodies
 

PROTEIN VIEW

? »
 
 
 
MAP3K1-001
 
 
 
 
 

PROTEIN INFORMATION

? »

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

MAP3K1-001 ENSP00000382423
ENST00000399503
Q13233
Show all »
Show » Show » 1512 164.5 No 1