SNAP23

GENE INFORMATION

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Gene name

SNAP23 (HGNC Symbol)

Synonyms

HsT17016, SNAP23A, SNAP23B

Description

Synaptosomal-associated protein, 23kDa (HGNC Symbol)

Entrez gene summary

Specificity of vesicular transport is regulated, in part, by the interaction of a vesicle-associated membrane protein termed synaptobrevin/VAMP with a target compartment membrane protein termed syntaxin. These proteins, together with SNAP25 (synaptosome-associated protein of 25 kDa), form a complex which serves as a binding site for the general membrane fusion machinery. Synaptobrevin/VAMP and syntaxin are believed to be involved in vesicular transport in most, if not all cells, while SNAP25 is present almost exclusively in the brain, suggesting that a ubiquitously expressed homolog of SNAP25 exists to facilitate transport vesicle/target membrane fusion in other tissues. The protein encoded by this gene is structurally and functionally similar to SNAP25 and binds tightly to multiple syntaxins and synaptobrevins/VAMPs. It is an essential component of the high affinity receptor for the general membrane fusion machinery and is an important regulator of transport vesicle docking and fusion. Two alternative transcript variants encoding different protein isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

Chromosome

15

Cytoband

Chromosome location (bp)

42491233 - 42545356

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000092531 (version 78.38)

Entrez gene

8773

UniProt

O00161 (UniProt - Evidence at protein level)

neXtProt

NX_O00161

Antibodypedia

SNAP23 antibodies
 

PROTEIN VIEW

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SNAP23-001
 
SNAP23-002
 
SNAP23-003
 
SNAP23-008
 
SNAP23-009
 
SNAP23-012
 
SNAP23-015
 
SNAP23-017
 
SNAP23-018
 
SNAP23-019
 
SNAP23-201
 
 » 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SNAP23-001 ENSP00000249647
ENST00000249647
O00161
Show all »
Show » Show » 211 23.4 No 0
SNAP23-002 ENSP00000380327
ENST00000397138
O00161
Show all »
Show » Show » 158 17.8 No 0
SNAP23-003 ENSP00000454214
ENST00000561526
H3BM38
Show all »
Show » Show » 125 13.9 No 0
SNAP23-008 ENSP00000455339
ENST00000564153
H3BPJ0
Show all »
Show » Show » 127 14.3 No 0
SNAP23-009 ENSP00000458012
ENST00000566327
H3BV99
Show all »
Show » Show » 142 15.6 No 0
SNAP23-012 ENSP00000456035
ENST00000568859
H3BR18
Show all »
Show » Show » 109 12.3 No 0
SNAP23-015 ENSP00000455472
ENST00000567094
H3BNE1
Show all »
Show » Show » 97 11.1 No 0
SNAP23-017 ENSP00000456000
ENST00000563830
Show » Show » 154 16.9 No 0
SNAP23-018 ENSP00000455102
ENST00000568841
Show » Show » 149 16.2 No 0
SNAP23-019 ENSP00000456144
ENST00000563873
Show » Show » 90 10.2 No 0
SNAP23-201 ENSP00000207062
ENST00000349777
O00161
Show all »
Show » Show » 158 17.8 No 0