LAMB1

GENE INFORMATION

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Gene name

LAMB1 (HGNC Symbol)

Synonyms

CLM

Description

Laminin, beta 1 (HGNC Symbol)

Entrez gene summary

Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins are composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively) and they form a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. Several isoforms of each chain have been described. Different alpha, beta and gamma chain isomers combine to give rise to different heterotrimeric laminin isoforms which are designated by Arabic numerals in the order of their discovery, i.e. alpha1beta1gamma1 heterotrimer is laminin 1. The biological functions of the different chains and trimer molecules are largely unknown, but some of the chains have been shown to differ with respect to their tissue distribution, presumably reflecting diverse functions in vivo. This gene encodes the beta chain isoform laminin, beta 1. The beta 1 chain has 7 structurally distinct domains which it shares with other beta chain isomers. The C-terminal helical region containing domains I and II are separated by domain alpha, domains III and V contain several EGF-like repeats, and domains IV and VI have a globular conformation. Laminin, beta 1 is expressed in most tissues that produce basement membranes, and is one of the 3 chains constituting laminin 1, the first laminin isolated from Engelbreth-Holm-Swarm (EHS) tumor. A sequence in the beta 1 chain that is involved in cell attachment, chemotaxis, and binding to the laminin receptor was identified and shown to have the capacity to inhibit metastasis. [provided by RefSeq, Aug 2011]

Chromosome

7

Cytoband

q31.1

Chromosome location (bp)

107923799 - 108003255

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000091136 (version 78.38)

Entrez gene

3912

UniProt

P07942 (UniProt - Evidence at protein level)

neXtProt

NX_P07942

Antibodypedia

LAMB1 antibodies
 

PROTEIN VIEW

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LAMB1-001
 
LAMB1-002
 
LAMB1-003
 
LAMB1-005
 
LAMB1-006
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

LAMB1-001 ENSP00000222399
ENST00000222399
P07942
Show all »
Show » Show » 1786 198 Yes 0
LAMB1-002 ENSP00000377190
ENST00000393560
E7EPA6
Show all »
Show » 850 95.1 Yes 0
LAMB1-003 ENSP00000377191
ENST00000393561
G3XAI2
Show all »
Show » Show » 1810 200.5 No 0
LAMB1-005 ENSP00000412686
ENST00000439976
C9J296
Show all »
Show » 183 20 Yes 0
LAMB1-006 ENSP00000377189
ENST00000393559
E9PCS6
Show all »
Show » 91 10.1 Yes 0