FXYD5

GENE INFORMATION

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Gene name

FXYD5 (HGNC Symbol)

Synonyms

OIT2

Description

FXYD domain containing ion transport regulator 5 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. Mouse FXYD5 has been termed RIC (Related to Ion Channel). FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. Transmembrane topology has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. This gene product, FXYD5, is a glycoprotein that functions in the up-regulation of chemokine production, and it is involved in the reduction of cell adhesion via its ability to down-regulate E-cadherin. It also promotes metastasis, and has been linked to a variety of cancers. Alternative splicing results in multiple transcript variants. [RefSeq curation by Kathleen J. Sweadner, Ph.D., sweadner@helix.mgh.harvard.edu., Sep 2009]

Chromosome

19

Cytoband

q13.12

Chromosome location (bp)

35154730 - 35169883

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000089327 (version 78.38)

Entrez gene

53827

UniProt

Q96DB9 (UniProt - Evidence at protein level)

neXtProt

NX_Q96DB9

Antibodypedia

FXYD5 antibodies
 

PROTEIN VIEW

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FXYD5-001
 
FXYD5-002
 
FXYD5-003
 
FXYD5-004
 
FXYD5-007
 
FXYD5-010
 
FXYD5-011
 
FXYD5-012
 
FXYD5-013
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

FXYD5-001 ENSP00000344254
ENST00000342879
Q96DB9
Show all »
Show » Show » 178 19.5 Yes 1
FXYD5-002 ENSP00000376053
ENST00000392219
Q96DB9
Show all »
Show » Show » 178 19.5 Yes 1
FXYD5-003 ENSP00000376051
ENST00000392217
Q96DB9
Show all »
Show » Show » 107 11.9 No 1
FXYD5-004 ENSP00000444839
ENST00000543307
F5H4X8
Show all »
Show » Show » 194 21.1 Yes 1
FXYD5-007 ENSP00000376052
ENST00000392218
A8MVG1
Show all »
Show » 96 10.3 Yes 1
FXYD5-010 ENSP00000467053
ENST00000588699
F5H4X8
Show all »
Show » Show » 194 21.1 Yes 1
FXYD5-011 ENSP00000393848
ENST00000423817
Q96DB9
Show all »
Show » Show » 178 19.5 Yes 1
FXYD5-012 ENSP00000465667
ENST00000590686
Q96DB9
Show all »
Show » Show » 178 19.5 Yes 1
FXYD5-013 ENSP00000443390
ENST00000541435
Q96DB9
Show all »
Show » Show » 178 19.5 Yes 1