P2RX7

GENE INFORMATION

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Gene name

P2RX7 (HGNC Symbol)

Synonyms

MGC20089, P2X7

Description

Purinergic receptor P2X, ligand-gated ion channel, 7 (HGNC Symbol)

Entrez gene summary

The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and is responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Activation of this nuclear receptor by ATP in the cytoplasm may be a mechanism by which cellular activity can be coupled to changes in gene expression. Multiple alternatively spliced variants have been identified, most of which fit nonsense-mediated decay (NMD) criteria. [provided by RefSeq, Jul 2010]

Chromosome

12

Cytoband

q24.31

Chromosome location (bp)

121132819 - 121188032

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000089041 (version 78.38)

Entrez gene

5027

UniProt

Q99572 (UniProt - Evidence at protein level)

neXtProt

NX_Q99572

Antibodypedia

P2RX7 antibodies
 

PROTEIN VIEW

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P2RX7-008
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

P2RX7-008 ENSP00000330696
ENST00000328963
Q99572
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