DOCK3

GENE INFORMATION

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Gene name

DOCK3 (HGNC Symbol)

Synonyms

KIAA0299, MOCA, PBP

Description

Dedicator of cytokinesis 3 (HGNC Symbol)

Entrez gene summary

This gene is specifically expressed in the central nervous system (CNS). It encodes a member of the DOCK (dedicator of cytokinesis) family of guanine nucleotide exchange factors (GEFs). This protein, dedicator of cytokinesis 3 (DOCK3), is also known as modifier of cell adhesion (MOCA) and presenilin-binding protein (PBP). The DOCK3 and DOCK1, -2 and -4 share several conserved amino acids in their DHR-2 (DOCK homology region 2) domains that are required for GEF activity, and bind directly to WAVE proteins [Wiskott-Aldrich syndrome protein (WASP) family Verprolin-homologous proteins] via their DHR-1 domains. The DOCK3 induces axonal outgrowth in CNS by stimulating membrane recruitment of the WAVE complex and activating the small G protein Rac1. This gene is associated with an attention deficit hyperactivity disorder-like phenotype by a complex chromosomal rearrangement. [provided by RefSeq, Aug 2010]

Chromosome

3

Cytoband

p21.2

Chromosome location (bp)

50675241 - 51384198

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000088538 (version 78.38)

Entrez gene

1795

UniProt

Q8IZD9 (UniProt - Evidence at protein level)

neXtProt

NX_Q8IZD9

Antibodypedia

DOCK3 antibodies
 

PROTEIN VIEW

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DOCK3-001
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

DOCK3-001 ENSP00000266037
ENST00000266037
Q8IZD9
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