BAX

GENERAL INFORMATION

? »

Gene name

BAX

Gene description

BCL2-associated X protein

Protein class

Cancer-related genes
Mitochondrial proteins
Predicted intracellular proteins
Transporters

Predicted localization

Intracellular

Number of transcripts

7
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

? »

RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Widely distributed cytoplasmic staining.

ANTIBODY RELIABILITY

? »

Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Supportive based on 2 antibodies.
HPA027878 , CAB004206
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

? »
RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

? »

Organ

Expression



RNA EXPRESSION OVERVIEW

? »
HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

? »

Gene name

BAX (HGNC Symbol)

Synonyms

BCL2L4

Description

BCL2-associated X protein (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein forms a heterodimer with BCL2, and functions as an apoptotic activator. This protein is reported to interact with, and increase the opening of, the mitochondrial voltage-dependent anion channel (VDAC), which leads to the loss in membrane potential and the release of cytochrome c. The expression of this gene is regulated by the tumor suppressor P53 and has been shown to be involved in P53-mediated apoptosis. Multiple alternatively spliced transcript variants, which encode different isoforms, have been reported for this gene. [provided by RefSeq, Jul 2008]

Chromosome

19

Cytoband

q13.33

Chromosome location (bp)

48954815 - 48961798

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000087088 (version 78.38)

Entrez gene

581

UniProt

Q07812 (UniProt - Evidence at protein level)

neXtProt

NX_Q07812

Antibodypedia

BAX antibodies


PROTEIN BROWSER

? »
 
 
 
ENST00000293288
 
ENST00000345358
 
ENST00000354470
 
ENST00000391871
 
ENST00000415969
 
ENST00000506183
 
ENST00000539787
 
 
 
 


PROTEIN INFORMATION

? »

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

BAX-001 ENSP00000293288
ENST00000293288
Q07812
Show all »
Show » Show » 218 24.2 No 0
BAX-003 ENSP00000389971
ENST00000415969
Q07812
Show all »
Show » Show » 179 19.7 No 0
BAX-004 ENSP00000426184
ENST00000506183
Q9UEI8
Show all »
Show » Show » 126 14.1 No 0
BAX-005 ENSP00000346461
ENST00000354470
Q07812
Show all »
Show » Show » 143 15.8 No 0
BAX-006 ENSP00000263262
ENST00000345358
Q07812
Show all »
Show » Show » 192 21.2 No 0
BAX-201 ENSP00000375744
ENST00000391871
K4JQN1
Show all »
Show » Show » 175 19.3 No 0
BAX-202 ENSP00000441413
ENST00000539787
I6LPK7
Show all »
Show » Show » 140 15.9 No 0