GCKR

GENERAL INFORMATION

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Gene name

GCKR

Gene description

Glucokinase (hexokinase 4) regulator

Protein class

Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

3
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Tissue enriched (liver)
GTEx:Tissue enriched (liver)

Protein evidence

Evidence at protein level

Protein localization

Selective nuclear expression in hepatocytes and subset of cells in stomach mucosa.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining consistent with RNA expression data.

Data reliability

Supportive based on 1 antibody.
CAB034098
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Stomach

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Tissue enriched (liver)

Organ

Expression

GTEx dataset
RNA tissue category:  Tissue enriched (liver)

Organ

Expression



GENE INFORMATION

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Gene name

GCKR

Synonyms

Description

Glucokinase (hexokinase 4) regulator (HGNC Symbol)

Entrez gene summary

This gene encodes a protein belonging to the GCKR subfamily of the SIS (Sugar ISomerase) family of proteins. The gene product is a regulatory protein that inhibits glucokinase in liver and pancreatic islet cells by binding non-covalently to form an inactive complex with the enzyme. This gene is considered a susceptibility gene candidate for a form of maturity-onset diabetes of the young (MODY). [provided by RefSeq, Jul 2008]

Chromosome

2

Cytoband

p23.3

Chromosome location (bp)

27496842 - 27523684

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000084734 (version 78.38)

Entrez gene

2646

UniProt

Q14397 (UniProt - Evidence at protein level)

neXtProt

NX_Q14397

Antibodypedia

GCKR antibodies


PROTEIN BROWSER

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ENST00000264717
 
ENST00000411584
 
ENST00000453813
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

GCKR-001 ENSP00000264717
ENST00000264717
Q14397
Show all »
Show » Show » 625 68.7 No 0
GCKR-004 ENSP00000399463
ENST00000453813
H7C1B4
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Show » Show » 227 24.4 No 0
GCKR-006 ENSP00000416917
ENST00000411584
Show » 189 21.2 No 0