REST

GENERAL INFORMATION

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Gene name

REST

Gene description

RE1-silencing transcription factor

Protein class

Plasma proteins
Predicted intracellular proteins
Transcription factors

Predicted localization

Intracellular

Number of transcripts

6
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Mixed

Protein evidence

Evidence at protein level

Protein localization

General nuclear expression.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Supportive based on 2 antibodies.
HPA006079 , CAB068222
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Bone marrow

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Mixed

Organ

Expression



GENE INFORMATION

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Gene name

REST (HGNC Symbol)

Synonyms

NRSF, XBR

Description

RE1-silencing transcription factor (HGNC Symbol)

Entrez gene summary

This gene encodes a transcriptional repressor that represses neuronal genes in non-neuronal tissues. It is a member of the Kruppel-type zinc finger transcription factor family. It represses transcription by binding a DNA sequence element called the neuron-restrictive silencer element. The protein is also found in undifferentiated neuronal progenitor cells and it is thought that this repressor may act as a master negative regular of neurogenesis. Alternatively spliced transcript variants have been described [provided by RefSeq, Jul 2010]

Chromosome

4

Cytoband

q12

Chromosome location (bp)

56907876 - 56935844

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000084093 (version 78.38)

Entrez gene

5978

UniProt

Q13127 (UniProt - Evidence at protein level)

neXtProt

NX_Q13127

Antibodypedia

REST antibodies


PROTEIN BROWSER

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ENST00000309042
 
ENST00000611211
 
ENST00000612429
 
ENST00000616975
 
ENST00000619101
 
ENST00000622863
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

REST-001 ENSP00000311816
ENST00000309042
Q13127
Show all »
Show » Show » 1097 121.9 No 0
REST-201 ENSP00000479151
ENST00000611211
Show » Show » 340 38.2 No 0
REST-202 ENSP00000484206
ENST00000612429
L0B3Z2
Show all »
Show » Show » 342 38.5 No 0
REST-203 ENSP00000484058
ENST00000616975
Show » Show » 340 38.2 No 0
REST-204 ENSP00000484836
ENST00000619101
Q13127
Show all »
Show » Show » 1097 121.9 No 0
REST-205 ENSP00000481650
ENST00000622863
L0B1S6
Show all »
Show » Show » 314 34.9 No 0