XPO1 - Gene info - The Human Protein Atlas

Gene name

XPO1 (HGNC Symbol)

Synonyms

CRM1, emb

Description

Exportin 1 (HGNC Symbol)

Entrez gene summary

This cell-cycle-regulated gene encodes a protein that mediates leucine-rich nuclear export signal (NES)-dependent protein transport. The protein specifically inhibits the nuclear export of Rev and U snRNAs. It is involved in the control of several cellular processes by controlling the localization of cyclin B, MPAK, and MAPKAP kinase 2. This protein also regulates NFAT and AP-1. [provided by RefSeq, Jan 2015]

Chromosome

Cytoband

p15

Chromosome location (bp)

61477849 - 61538626

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000082898 (version 78.38)

Entrez gene

7514

UniProt

O14980 (UniProt - Evidence at protein level)

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

XPO1-001

ENSP00000384863
ENST00000401558

O14980
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O14980 [Direct mapping]
Exportin-1
B7ZB16 [Target identity:72%; Query identity:100%]
cDNA, FLJ79380, highly similar to Exportin-1 {ECO:0000313|EMBL:BAH14852.1}
B3KWD0 [Target identity:67%; Query identity:100%]
cDNA FLJ42779 fis, clone BRAWH3005300, highly similar to Exportin-1 {ECO:0000313|EMBL:BAG54092.1}
C9JKM9 [Target identity:16%; Query identity:100%]
Exportin-1 {ECO:0000313|Ensembl:ENSP00000413853}
C9J673 [Target identity:12%; Query identity:100%]
Exportin-1 {ECO:0000313|Ensembl:ENSP00000406428}
C9JV99 [Target identity:9%; Query identity:100%]
Exportin-1 {ECO:0000313|Ensembl:ENSP00000393484}
C9IZS4 [Target identity:8%; Query identity:100%]
Uncharacterized protein {ECO:0000313|Ensembl:ENSP00000394951}
C9JQ02 [Target identity:8%; Query identity:100%]
Exportin-1 {ECO:0000313|Ensembl:ENSP00000408190}
C9IYM2 [Target identity:5%; Query identity:100%]
Exportin-1 {ECO:0000313|Ensembl:ENSP00000406819}
C9JF49 [Target identity:5%; Query identity:100%]
Exportin-1 {ECO:0000313|Ensembl:ENSP00000390843}

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Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Mutated cancer genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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GO:0000055 [ribosomal large subunit export from nucleus]
GO:0000056 [ribosomal small subunit export from nucleus]
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000278 [mitotic cell cycle]
GO:0000776 [kinetochore]
GO:0003723 [RNA binding]
GO:0005215 [transporter activity]
GO:0005487 [nucleocytoplasmic transporter activity]
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005635 [nuclear envelope]
GO:0005642 [annulate lamellae]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006611 [protein export from nucleus]
GO:0006886 [intracellular protein transport]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0008536 [Ran GTPase binding]
GO:0008565 [protein transporter activity]
GO:0010467 [gene expression]
GO:0010824 [regulation of centrosome duplication]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0016070 [RNA metabolic process]
GO:0016071 [mRNA metabolic process]
GO:0019058 [viral life cycle]
GO:0019904 [protein domain specific binding]
GO:0030512 [negative regulation of transforming growth factor beta receptor signaling pathway]
GO:0030529 [ribonucleoprotein complex]
GO:0031965 [nuclear membrane]
GO:0034504 [protein localization to nucleus]
GO:0042176 [regulation of protein catabolic process]
GO:0042493 [response to drug]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0046825 [regulation of protein export from nucleus]
GO:0051028 [mRNA transport]
GO:0075733 [intracellular transport of virus]

1071

123.4

XPO1-004

ENSP00000385559
ENST00000406957

O14980
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GO:0000055 [ribosomal large subunit export from nucleus]
GO:0000056 [ribosomal small subunit export from nucleus]
GO:0000278 [mitotic cell cycle]
GO:0000776 [kinetochore]
GO:0003723 [RNA binding]
GO:0005215 [transporter activity]
GO:0005487 [nucleocytoplasmic transporter activity]
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005635 [nuclear envelope]
GO:0005642 [annulate lamellae]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006611 [protein export from nucleus]
GO:0006886 [intracellular protein transport]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0008536 [Ran GTPase binding]
GO:0010467 [gene expression]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0016070 [RNA metabolic process]
GO:0016071 [mRNA metabolic process]
GO:0019058 [viral life cycle]
GO:0030512 [negative regulation of transforming growth factor beta receptor signaling pathway]
GO:0030529 [ribonucleoprotein complex]
GO:0031965 [nuclear membrane]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0051028 [mRNA transport]
GO:0075733 [intracellular transport of virus]

1071

123.4

XPO1-006

ENSP00000385942
ENST00000404992

O14980
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1071

123.4

XPO1-008

ENSP00000406428
ENST00000443240

C9J673
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C9J673 [Target identity:100%; Query identity:100%]
Exportin-1 {ECO:0000313|Ensembl:ENSP00000406428}
C9JV99 [Target identity:75%; Query identity:100%]
Exportin-1 {ECO:0000313|Ensembl:ENSP00000393484}
C9IZS4 [Target identity:71%; Query identity:100%]
Uncharacterized protein {ECO:0000313|Ensembl:ENSP00000394951}
C9JQ02 [Target identity:71%; Query identity:100%]
Exportin-1 {ECO:0000313|Ensembl:ENSP00000408190}
C9IYM2 [Target identity:46%; Query identity:100%]
Exportin-1 {ECO:0000313|Ensembl:ENSP00000406819}
C9JF49 [Target identity:44%; Query identity:100%]
Exportin-1 {ECO:0000313|Ensembl:ENSP00000390843}

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Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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GO:0005488 [binding]
GO:0006886 [intracellular protein transport]
GO:0008536 [Ran GTPase binding]

132

15.2

XPO1-009

ENSP00000390843
ENST00000436018

C9JF49
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C9JF49 [Target identity:100%; Query identity:100%]
Exportin-1 {ECO:0000313|Ensembl:ENSP00000390843}

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GO:0005488 [binding]

6.7

XPO1-015

ENSP00000413853
ENST00000451765

C9JKM9
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C9JKM9 [Target identity:100%; Query identity:100%]
Exportin-1 {ECO:0000313|Ensembl:ENSP00000413853}
C9J673 [Target identity:73%; Query identity:100%]
Exportin-1 {ECO:0000313|Ensembl:ENSP00000406428}
C9JV99 [Target identity:55%; Query identity:100%]
Exportin-1 {ECO:0000313|Ensembl:ENSP00000393484}
C9JQ02 [Target identity:53%; Query identity:100%]
Exportin-1 {ECO:0000313|Ensembl:ENSP00000408190}
C9IZS4 [Target identity:52%; Query identity:100%]
Uncharacterized protein {ECO:0000313|Ensembl:ENSP00000394951}
C9IYM2 [Target identity:34%; Query identity:100%]
Exportin-1 {ECO:0000313|Ensembl:ENSP00000406819}
C9JF49 [Target identity:32%; Query identity:100%]
Exportin-1 {ECO:0000313|Ensembl:ENSP00000390843}

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GO:0005488 [binding]
GO:0006886 [intracellular protein transport]
GO:0008536 [Ran GTPase binding]

179

20.6

XPO1-016

ENSP00000406819
ENST00000449444

C9IYM2
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C9IYM2 [Target identity:100%; Query identity:100%]
Exportin-1 {ECO:0000313|Ensembl:ENSP00000406819}
C9JF49 [Target identity:95%; Query identity:100%]
Exportin-1 {ECO:0000313|Ensembl:ENSP00000390843}

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GO:0005488 [binding]

7.1

XPO1-017

ENSP00000394951
ENST00000457483

C9IZS4
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C9IZS4 [Target identity:100%; Query identity:100%]
Uncharacterized protein {ECO:0000313|Ensembl:ENSP00000394951}
C9IYM2 [Target identity:65%; Query identity:100%]
Exportin-1 {ECO:0000313|Ensembl:ENSP00000406819}
C9JF49 [Target identity:62%; Query identity:100%]
Exportin-1 {ECO:0000313|Ensembl:ENSP00000390843}

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GO:0005488 [binding]
GO:0006886 [intracellular protein transport]
GO:0008536 [Ran GTPase binding]

XPO1-018

ENSP00000408190
ENST00000422552

C9JQ02
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C9JQ02 [Target identity:100%; Query identity:100%]
Exportin-1 {ECO:0000313|Ensembl:ENSP00000408190}
C9IZS4 [Target identity:98%; Query identity:100%]
Uncharacterized protein {ECO:0000313|Ensembl:ENSP00000394951}
C9IYM2 [Target identity:65%; Query identity:100%]
Exportin-1 {ECO:0000313|Ensembl:ENSP00000406819}
C9JF49 [Target identity:62%; Query identity:100%]
Exportin-1 {ECO:0000313|Ensembl:ENSP00000390843}

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GO:0005488 [binding]
GO:0006886 [intracellular protein transport]
GO:0008536 [Ran GTPase binding]

11.1

XPO1-019

ENSP00000393484
ENST00000420673

C9JV99
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C9JV99 [Target identity:100%; Query identity:100%]
Exportin-1 {ECO:0000313|Ensembl:ENSP00000393484}
C9JQ02 [Target identity:95%; Query identity:100%]
Exportin-1 {ECO:0000313|Ensembl:ENSP00000408190}
C9IZS4 [Target identity:94%; Query identity:100%]
Uncharacterized protein {ECO:0000313|Ensembl:ENSP00000394951}
C9IYM2 [Target identity:62%; Query identity:100%]
Exportin-1 {ECO:0000313|Ensembl:ENSP00000406819}
C9JF49 [Target identity:59%; Query identity:100%]
Exportin-1 {ECO:0000313|Ensembl:ENSP00000390843}

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GO:0005488 [binding]
GO:0006886 [intracellular protein transport]
GO:0008536 [Ran GTPase binding]

100

11.7

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.