AP4E1

GENE INFORMATION

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Gene name

AP4E1 (HGNC Symbol)

Synonyms

AP-4-EPSILON, SPG51

Description

Adaptor-related protein complex 4, epsilon 1 subunit (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the adaptor complexes large subunit protein family. These proteins are components of the heterotetrameric adaptor protein complexes, which play important roles in the secretory and endocytic pathways by mediating vesicle formation and sorting of integral membrane proteins. The encoded protein is a large subunit of adaptor protein complex-4, which is associated with both clathrin- and nonclathrin-coated vesicles. Disruption of this gene may be associated with cerebral palsy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]

Chromosome

15

Cytoband

q21.2

Chromosome location (bp)

50908672 - 51005900

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000081014 (version 78.38)

Entrez gene

23431

UniProt

Q9UPM8 (UniProt - Evidence at protein level)

neXtProt

NX_Q9UPM8

Antibodypedia

AP4E1 antibodies
 

PROTEIN VIEW

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AP4E1-001
 
AP4E1-002
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

AP4E1-001 ENSP00000261842
ENST00000261842
Q9UPM8
Show all »
Show » Show » 1137 127.3 No 0
AP4E1-002 ENSP00000452976
ENST00000560508
Q9UPM8
Show all »
Show » Show » 1062 119.5 No 0