RBL1

GENERAL INFORMATION

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Gene name

RBL1

Gene description

Retinoblastoma-like 1

Protein class

Cancer-related genes
Plasma proteins
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

Intracellular,Membrane

Number of transcripts

3
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Mixed

Protein evidence

Evidence at protein level

Protein localization

Nuclear expression in most cell types.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Supportive based on 2 antibodies.
HPA054962 , HPA056525
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Nasopharynx
N/A
N/A
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Mixed

Organ

Expression



GENE INFORMATION

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Gene name

RBL1 (HGNC Symbol)

Synonyms

cp107, p107, PRB1

Description

Retinoblastoma-like 1 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is similar in sequence and possibly function to the product of the retinoblastoma 1 (RB1) gene. The RB1 gene product is a tumor suppressor protein that appears to be involved in cell cycle regulation, as it is phosphorylated in the S to M phase transition and is dephosphorylated in the G1 phase of the cell cycle. Both the RB1 protein and the product of this gene can form a complex with adenovirus E1A protein and SV40 large T-antigen, with the SV40 large T-antigen binding only to the unphosphorylated form of each protein. In addition, both proteins can inhibit the transcription of cell cycle genes containing E2F binding sites in their promoters. Due to the sequence and biochemical similarities with the RB1 protein, it is thought that the protein encoded by this gene may also be a tumor suppressor. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

20

Cytoband

q11.23

Chromosome location (bp)

36996349 - 37095995

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000080839 (version 78.38)

Entrez gene

5933

UniProt

P28749 (UniProt - Evidence at protein level)

neXtProt

NX_P28749

Antibodypedia

RBL1 antibodies


PROTEIN BROWSER

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ENST00000344359
 
ENST00000373664
 
ENST00000525052
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

RBL1-001 ENSP00000362768
ENST00000373664
P28749
Show all »
Show » Show » 1068 120.8 No 1
RBL1-002 ENSP00000343646
ENST00000344359
P28749
Show all »
Show » Show » 1014 114.7 No 1
RBL1-004 ENSP00000434711
ENST00000525052
Show » Show » 255 28.8 No 0