CHRNA3

GENE INFORMATION

? »

Gene name

CHRNA3

Synonyms

Description

Cholinergic receptor, nicotinic, alpha 3 (neuronal) (HGNC Symbol)

Entrez gene summary

This locus encodes a member of the nicotinic acetylcholine receptor family of proteins. Members of this family of proteins form pentameric complexes comprised of both alpha and beta subunits. This locus encodes an alpha-type subunit, as it contains characteristic adjacent cysteine residues. The encoded protein is a ligand-gated ion channel that likely plays a role in neurotransmission. Polymorphisms in this gene have been associated with an increased risk of smoking initiation and an increased susceptibility to lung cancer. Alternatively spliced transcript variants have been described. [provided by RefSeq, Nov 2009]

Chromosome

15

Cytoband

q25.1

Chromosome location (bp)

78593052 - 78621295

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000080644 (version 78.38)

Entrez gene

1136

UniProt

P32297 (UniProt - Evidence at protein level)

neXtProt

NX_P32297

Antibodypedia

CHRNA3 antibodies
 

PROTEIN VIEW

? »
 
 
 
CHRNA3-001
 
CHRNA3-002
 
CHRNA3-007
 
 
 
 
 

PROTEIN INFORMATION

? »

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CHRNA3-001 ENSP00000315602
ENST00000326828
P32297
Show all »
Show » Show » 505 57.5 Yes 4
CHRNA3-002 ENSP00000267951
ENST00000348639
P32297
Show all »
Show » Show » 489 55.6 Yes 3
CHRNA3-007 ENSP00000453993
ENST00000559080
Show » 18 2.1 No 0