CEACAM1

GENERAL INFORMATION

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Gene name

CEACAM1

Gene description

Carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)

Protein class

CD markers
Plasma proteins
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

Intracellular,Membrane

Number of transcripts

8
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Tissue enhanced (colon, rectum)
GTEx:Tissue enhanced (colon)

Protein evidence

Evidence at protein level

Protein localization

Membranous expression in a few tissues, most abundant in glandular epithelia of the gastrointestinal tract, bile canaliculi of liver and intercalated ducts of salivary gland.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining mainly consistent with RNA expression data. Caution, targets protein from more than one gene.

Data reliability

Supportive based on 2 antibodies.
HPA011041 , CAB002146
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Tissue enhanced (colon, rectum)

Organ

Expression

GTEx dataset
RNA tissue category:  Tissue enhanced (colon)

Organ

Expression



GENE INFORMATION

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Gene name

CEACAM1 (HGNC Symbol)

Synonyms

BGP, BGP1, CD66a

Description

Carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the carcinoembryonic antigen (CEA) gene family, which belongs to the immunoglobulin superfamily. Two subgroups of the CEA family, the CEA cell adhesion molecules and the pregnancy-specific glycoproteins, are located within a 1.2 Mb cluster on the long arm of chromosome 19. Eleven pseudogenes of the CEA cell adhesion molecule subgroup are also found in the cluster. The encoded protein was originally described in bile ducts of liver as biliary glycoprotein. Subsequently, it was found to be a cell-cell adhesion molecule detected on leukocytes, epithelia, and endothelia. The encoded protein mediates cell adhesion via homophilic as well as heterophilic binding to other proteins of the subgroup. Multiple cellular activities have been attributed to the encoded protein, including roles in the differentiation and arrangement of tissue three-dimensional structure, angiogenesis, apoptosis, tumor suppression, metastasis, and the modulation of innate and adaptive immune responses. Multiple transcript variants encoding different isoforms have been reported, but the full-length nature of all variants has not been defined. [provided by RefSeq, May 2010]

Chromosome

19

Cytoband

q13.2

Chromosome location (bp)

42507304 - 42561234

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000079385 (version 78.38)

Entrez gene

634

UniProt

P13688 (UniProt - Evidence at protein level)

neXtProt

NX_P13688

Antibodypedia

CEACAM1 antibodies


PROTEIN BROWSER

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ENST00000161559
 
ENST00000352591
 
ENST00000358394
 
ENST00000403444
 
ENST00000403461
 
ENST00000471298
 
ENST00000599389
 
ENST00000600172
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CEACAM1-001 ENSP00000161559
ENST00000161559
P13688
Show all »
Show » Show » 526 57.6 Yes 1
CEACAM1-002 ENSP00000384709
ENST00000403444
P13688
Show all »
Show » Show » 464 50.5 Yes 1
CEACAM1-006 ENSP00000384083
ENST00000403461
P13688
Show all »
Show » Show » 368 39.9 Yes 1
CEACAM1-007 ENSP00000472633
ENST00000471298
M0R2K4
Show all »
Show » 94 10.4 No 0
CEACAM1-011 ENSP00000244291
ENST00000352591
P13688
Show all »
Show » Show » 430 46.9 Yes 1
CEACAM1-012 ENSP00000351165
ENST00000358394
P13688
Show all »
Show » Show » 461 50.3 Yes 1
CEACAM1-013 ENSP00000471918
ENST00000599389
P13688
Show all »
Show » Show » 399 43.1 Yes 1
CEACAM1-014 ENSP00000471566
ENST00000600172
M0R109
Show all »
Show » 99 11 No 0