ITCH

GENERAL INFORMATION

? »

Gene name

ITCH

Gene description

Itchy E3 ubiquitin protein ligase

Protein class

Disease related genes
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

5
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

? »

RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Ubiquitous cytoplasmic expression.

ANTIBODY RELIABILITY

? »

Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Data reliability

Supportive based on 1 antibody.
HPA021126
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

? »
RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

? »

Organ

Expression



RNA EXPRESSION OVERVIEW

? »
HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

? »

Gene name

ITCH (HGNC Symbol)

Synonyms

AIP4

Description

Itchy E3 ubiquitin protein ligase (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the Nedd4 family of HECT domain E3 ubiquitin ligases. HECT domain E3 ubiquitin ligases transfer ubiquitin from E2 ubiquitin-conjugating enzymes to protein substrates, thus targeting specific proteins for lysosomal degradation. The encoded protein plays a role in multiple cellular processes including erythroid and lymphoid cell differentiation and the regulation of immune responses. Mutations in this gene are a cause of syndromic multisystem autoimmune disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012]

Chromosome

20

Cytoband

q11.22

Chromosome location (bp)

34363235 - 34511393

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000078747 (version 78.38)

Entrez gene

83737

UniProt

Q96J02 (UniProt - Evidence at protein level)

neXtProt

NX_Q96J02

Antibodypedia

ITCH antibodies


PROTEIN BROWSER

? »
 
 
 
ENST00000262650
 
ENST00000374864
 
ENST00000535650
 
ENST00000610336
 
ENST00000621101
 
 
 
 


PROTEIN INFORMATION

? »

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ITCH-001 ENSP00000363998
ENST00000374864
Q96J02
Show all »
Show » Show » 862 98.7 No 0
ITCH-002 ENSP00000262650
ENST00000262650
Q96J02
Show all »
Show » Show » 903 102.8 No 0
ITCH-201 ENSP00000445608
ENST00000535650
Q96J02
Show all »
Show » Show » 752 86.5 No 0
ITCH-202 ENSP00000484783
ENST00000610336
Q96J02
Show all »
Show » Show » 862 98.7 No 0
ITCH-203 ENSP00000480499
ENST00000621101
Q96J02
Show all »
Show » Show » 903 102.8 No 0