CBFA2T2

GENE INFORMATION

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Gene name

CBFA2T2 (HGNC Symbol)

Synonyms

MTGR1, ZMYND3

Description

Core-binding factor, runt domain, alpha subunit 2; translocated to, 2 (HGNC Symbol)

Entrez gene summary

In acute myeloid leukemia, especially in the M2 subtype, the t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 (AML1) gene fused to the 3'-region of the CBFA2T1 (MTG8) gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. The protein encoded by this gene binds to the AML1-MTG8 complex and may be important in promoting leukemogenesis. Several transcript variants are thought to exist for this gene, but the full-length natures of only three have been described. [provided by RefSeq, Jul 2008]

Chromosome

20

Cytoband

Chromosome location (bp)

33490075 - 33650036

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000078699 (version 78.38)

Entrez gene

9139

UniProt

O43439 (UniProt - Evidence at protein level)

neXtProt

NX_O43439

Antibodypedia

CBFA2T2 antibodies
 

PROTEIN VIEW

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CBFA2T2-003
 
CBFA2T2-004
 
CBFA2T2-005
 
CBFA2T2-007
 
CBFA2T2-009
 
CBFA2T2-201
 
CBFA2T2-202
 
CBFA2T2-203
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CBFA2T2-003 ENSP00000364428
ENST00000375279
O43439
Show all »
Show » Show » 604 67.1 No 0
CBFA2T2-004 ENSP00000433270
ENST00000492345
O43439
Show all »
Show » Show » 575 63.9 No 0
CBFA2T2-005 ENSP00000341865
ENST00000344201
O43439
Show all »
Show » Show » 263 28.6 No 0
CBFA2T2-007 ENSP00000352622
ENST00000359606
O43439
Show all »
Show » Show » 614 68 No 0
CBFA2T2-009 ENSP00000345810
ENST00000342704
O43439
Show all »
Show » Show » 595 65.9 No 0
CBFA2T2-201 ENSP00000262653
ENST00000346541
O43439
Show all »
Show » Show » 604 67.1 No 0
CBFA2T2-202 ENSP00000380902
ENST00000397800
O43439
Show all »
Show » Show » 575 63.9 No 0
CBFA2T2-203 ENSP00000443398
ENST00000543126
Q68DC6
Show all »
Show » Show » 152 16.5 No 0