NAALAD2

GENE INFORMATION

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Gene name

NAALAD2 (HGNC Symbol)

Synonyms

GPCIII, NAADALASE2, NAALADASE2

Description

N-acetylated alpha-linked acidic dipeptidase 2 (HGNC Symbol)

Entrez gene summary

This gene is a member of the N-acetylated alpha-linked acidic dipeptidase (NAALADase) gene family. The representative member of this family is the gene encoding human prostate-specific membrane antigen (PSM), which is a marker of prostatic carcinomas and is the first to be shown to possess NAALADase activity. NAALADase cleaves N-acetyl-L-aspartate-L-glutamate (NAAG), which is a neuropeptide expressed both in the central nervous systems and in the periphery and is thought to function as a neurotransmitter. The product of this gene is a type II integral membrane protein. Transient transfection of this gene confers both NAALADase and dipetidyl peptidase IV activities to mammalian cells. This gene is highly expressed in ovary and testis as well as within discrete brain areas. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]

Chromosome

11

Cytoband

q14.3

Chromosome location (bp)

90131515 - 90192894

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000077616 (version 78.38)

Entrez gene

10003

UniProt

Q9Y3Q0 (UniProt - Evidence at protein level)

neXtProt

NX_Q9Y3Q0

Antibodypedia

NAALAD2 antibodies
 

PROTEIN VIEW

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NAALAD2-001
 
NAALAD2-002
 
NAALAD2-006
 
NAALAD2-007
 
NAALAD2-008
 
NAALAD2-009
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

NAALAD2-001 ENSP00000432481
ENST00000534061
Q9Y3Q0
Show all »
Show » Show » 740 83.6 No 1
NAALAD2-002 ENSP00000320083
ENST00000321955
J3KNJ3
Show all »
Show » 707 80.2 No 1
NAALAD2-006 ENSP00000435249
ENST00000525171
E9PKX5
Show all »
Show » 372 42.2 No 1
NAALAD2-007 ENSP00000431989
ENST00000525497
E9PII2
Show all »
Show » 88 10.2 No 1
NAALAD2-008 ENSP00000435670
ENST00000526637
E9PJ53
Show all »
Show » 107 12.2 No 0
NAALAD2-009 ENSP00000365111
ENST00000375944
Q9Y3Q0
Show all »
Show » Show » 305 34.4 No 1