DCX

GENE INFORMATION

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Gene name

DCX (HGNC Symbol)

Synonyms

DBCN, DC, LISX, SCLH, XLIS

Description

Doublecortin (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the doublecortin family. The protein encoded by this gene is a cytoplasmic protein and contains two doublecortin domains, which bind microtubules. In the developing cortex, cortical neurons must migrate over long distances to reach the site of their final differentiation. The encoded protein appears to direct neuronal migration by regulating the organization and stability of microtubules. In addition, the encoded protein interacts with LIS1, the regulatory gamma subunit of platelet activating factor acetylhydrolase, and this interaction is important to proper microtubule function in the developing cortex. Mutations in this gene cause abnormal migration of neurons during development and disrupt the layering of the cortex, leading to epilepsy, mental retardation, subcortical band heterotopia (""double cortex"" syndrome) in females and lissencephaly (""smooth brain"" syndrome) in males. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2010]

Chromosome

X

Cytoband

q23

Chromosome location (bp)

111293780 - 111412375

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000077279 (version 78.38)

Entrez gene

1641

UniProt

O43602 (UniProt - Evidence at protein level)

neXtProt

NX_O43602

Antibodypedia

DCX antibodies
 

PROTEIN VIEW

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DCX-001
 
DCX-002
 
DCX-004
 
DCX-005
 
DCX-006
 
DCX-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

DCX-001 ENSP00000419861
ENST00000488120
O43602
Show all »
Show » Show » 360 40 No 0
DCX-002 ENSP00000350776
ENST00000358070
B4DM53
Show all »
Show » Show » 438 48.8 No 0
DCX-004 ENSP00000348553
ENST00000356220
O43602
Show all »
Show » Show » 365 40.6 No 0
DCX-005 ENSP00000418811
ENST00000468911
E7EU50
Show all »
Show » Show » 113 13.1 No 0
DCX-006 ENSP00000337697
ENST00000338081
O43602
Show all »
Show » Show » 441 49.3 No 0
DCX-201 ENSP00000361061
ENST00000371993
O43602
Show all »
Show » Show » 360 40 No 0