NFKB2 - Gene info - The Human Protein Atlas

Gene name

NFKB2 (HGNC Symbol)

Synonyms

LYT-10, NF-kB2, p105, p52

Description

Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) (HGNC Symbol)

Entrez gene summary

This gene encodes a subunit of the transcription factor complex nuclear factor-kappa-B (NFkB). The NFkB complex is expressed in numerous cell types and functions as a central activator of genes involved in inflammation and immune function. The protein encoded by this gene can function as both a transcriptional activator or repressor depending on its dimerization partner. The p100 full-length protein is co-translationally processed into a p52 active form. Chromosomal rearrangements and translocations of this locus have been observed in B cell lymphomas, some of which may result in the formation of fusion proteins. There is a pseudogene for this gene on chromosome 18. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]

Chromosome

Cytoband

q24.32

Chromosome location (bp)

102394110 - 102402529

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000077150 (version 78.38)

Entrez gene

4791

UniProt

Q00653 (UniProt - Evidence at protein level)

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

NFKB2-001

ENSP00000189444
ENST00000189444

Q00653
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Q00653 [Direct mapping]
Nuclear factor NF-kappa-B p100 subunit Nuclear factor NF-kappa-B p52 subunit
M0R119 [Target identity:7%; Query identity:100%]
Nuclear factor NF-kappa-B p100 subunit {ECO:0000313|Ensembl:ENSP00000471586}
M0QZX1 [Target identity:2%; Query identity:100%]
Nuclear factor NF-kappa-B p100 subunit {ECO:0000313|Ensembl:ENSP00000470826}

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Predicted intracellular proteins
Transcription factors
   Immunoglobulin fold
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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GO:0002224 [toll-like receptor signaling pathway]
GO:0002755 [MyD88-dependent toll-like receptor signaling pathway]
GO:0002756 [MyD88-independent toll-like receptor signaling pathway]
GO:0003677 [DNA binding]
GO:0003700 [sequence-specific DNA binding transcription factor activity]
GO:0003713 [transcription coactivator activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007165 [signal transduction]
GO:0032481 [positive regulation of type I interferon production]
GO:0033257 [Bcl3/NF-kappaB2 complex]
GO:0034134 [toll-like receptor 2 signaling pathway]
GO:0034138 [toll-like receptor 3 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0034146 [toll-like receptor 5 signaling pathway]
GO:0034162 [toll-like receptor 9 signaling pathway]
GO:0034166 [toll-like receptor 10 signaling pathway]
GO:0035666 [TRIF-dependent toll-like receptor signaling pathway]
GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway]
GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway]
GO:0045087 [innate immune response]
GO:0048511 [rhythmic process]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]

899

96.7

NFKB2-003

ENSP00000358983
ENST00000369966

Q00653
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GO:0002224 [toll-like receptor signaling pathway]
GO:0002268 [follicular dendritic cell differentiation]
GO:0002467 [germinal center formation]
GO:0002755 [MyD88-dependent toll-like receptor signaling pathway]
GO:0002756 [MyD88-independent toll-like receptor signaling pathway]
GO:0003677 [DNA binding]
GO:0003700 [sequence-specific DNA binding transcription factor activity]
GO:0003713 [transcription coactivator activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007165 [signal transduction]
GO:0030198 [extracellular matrix organization]
GO:0032481 [positive regulation of type I interferon production]
GO:0033257 [Bcl3/NF-kappaB2 complex]
GO:0034134 [toll-like receptor 2 signaling pathway]
GO:0034138 [toll-like receptor 3 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0034146 [toll-like receptor 5 signaling pathway]
GO:0034162 [toll-like receptor 9 signaling pathway]
GO:0034166 [toll-like receptor 10 signaling pathway]
GO:0035666 [TRIF-dependent toll-like receptor signaling pathway]
GO:0038061 [NIK/NF-kappaB signaling]
GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway]
GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway]
GO:0045087 [innate immune response]
GO:0048511 [rhythmic process]
GO:0048536 [spleen development]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]

900

96.7

NFKB2-004

ENSP00000471586
ENST00000471698

M0R119
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M0R119 [Target identity:100%; Query identity:100%]
Nuclear factor NF-kappa-B p100 subunit {ECO:0000313|Ensembl:ENSP00000471586}
M0QZX1 [Target identity:32%; Query identity:100%]
Nuclear factor NF-kappa-B p100 subunit {ECO:0000313|Ensembl:ENSP00000470826}

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Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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GO:0003700 [sequence-specific DNA binding transcription factor activity]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]

7.4

NFKB2-007

ENSP00000470826
ENST00000601386

M0QZX1
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M0QZX1 [Target identity:100%; Query identity:100%]
Nuclear factor NF-kappa-B p100 subunit {ECO:0000313|Ensembl:ENSP00000470826}

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2.5

NFKB2-201

ENSP00000410256
ENST00000428099

Q00653
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899

96.7

NFKB2-202

ENSP00000480211
ENST00000610498

M0R119
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M0R119 [Target identity:16%; Query identity:100%]
Nuclear factor NF-kappa-B p100 subunit {ECO:0000313|Ensembl:ENSP00000471586}
M0QZX1 [Target identity:5%; Query identity:100%]
Nuclear factor NF-kappa-B p100 subunit {ECO:0000313|Ensembl:ENSP00000470826}

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GO:0003700 [sequence-specific DNA binding transcription factor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]

415

45.6

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.