RAP1GAP

GENE INFORMATION

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Gene name

RAP1GAP (HGNC Symbol)

Synonyms

KIAA0474, RAP1GA1, RAP1GAP1, RAP1GAPII

Description

RAP1 GTPase activating protein (HGNC Symbol)

Entrez gene summary

This gene encodes a type of GTPase-activating-protein (GAP) that down-regulates the activity of the ras-related RAP1 protein. RAP1 acts as a molecular switch by cycling between an inactive GDP-bound form and an active GTP-bound form. The product of this gene, RAP1GAP, promotes the hydrolysis of bound GTP and hence returns RAP1 to the inactive state whereas other proteins, guanine nucleotide exchange factors (GEFs), act as RAP1 activators by facilitating the conversion of RAP1 from the GDP- to the GTP-bound form. In general, ras subfamily proteins, such as RAP1, play key roles in receptor-linked signaling pathways that control cell growth and differentiation. RAP1 plays a role in diverse processes such as cell proliferation, adhesion, differentiation, and embryogenesis. Alternative splicing results in multiple transcript variants encoding distinct proteins. [provided by RefSeq, Aug 2011]

Chromosome

1

Cytoband

p36.12

Chromosome location (bp)

21596215 - 21669363

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000076864 (version 78.38)

Entrez gene

5909

UniProt

P47736 (UniProt - Evidence at protein level)

neXtProt

NX_P47736

Antibodypedia

RAP1GAP antibodies
 

PROTEIN VIEW

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RAP1GAP-001
 
RAP1GAP-004
 
RAP1GAP-005
 
RAP1GAP-009
 
RAP1GAP-011
 
RAP1GAP-014
 
RAP1GAP-015
 
RAP1GAP-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

RAP1GAP-001 ENSP00000363897
ENST00000374765
P47736
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Show » Show » 663 73.4 No 0
RAP1GAP-004 ENSP00000363893
ENST00000374761
J3KPC5
Show all »
Show » Show » 694 76.7 No 0
RAP1GAP-005 ENSP00000315420
ENST00000317967
Q5T3T1
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Show » Show » 96 11 No 0
RAP1GAP-009 ENSP00000392717
ENST00000447293
Q5T3T0
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Show » Show » 36 4.3 No 0
RAP1GAP-011 ENSP00000434033
ENST00000495204
P47736
Show all »
Show » Show » 727 80.6 No 0
RAP1GAP-014 ENSP00000441661
ENST00000542643
P47736
Show all »
Show » Show » 681 75.2 No 0
RAP1GAP-015 ENSP00000363895
ENST00000374763
X6R8W7
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Show » Show » 748 81.7 No 0
RAP1GAP-201 ENSP00000290101
ENST00000290101
Q5T3T1
Show all »
Show » Show » 692 76.1 No 0