ADD2

GENE INFORMATION

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Gene name

ADD2 (HGNC Symbol)

Synonyms

ADDB

Description

Adducin 2 (beta) (HGNC Symbol)

Entrez gene summary

Adducins are heteromeric proteins composed of different subunits referred to as adducin alpha, beta and gamma. The three subunits are encoded by distinct genes and belong to a family of membrane skeletal proteins involved in the assembly of spectrin-actin network in erythrocytes and at sites of cell-cell contact in epithelial tissues. While adducins alpha and gamma are ubiquitously expressed, the expression of adducin beta is restricted to brain and hematopoietic tissues. Adducin, originally purified from human erythrocytes, was found to be a heterodimer of adducins alpha and beta. Polymorphisms resulting in amino acid substitutions in these two subunits have been associated with the regulation of blood pressure in an animal model of hypertension. Heterodimers consisting of alpha and gamma subunits have also been described. Structurally, each subunit is comprised of two distinct domains. The amino-terminal region is protease resistant and globular in shape, while the carboxy-terminal region is protease sensitive. The latter contains multiple phosphorylation sites for protein kinase C, the binding site for calmodulin, and is required for association with spectrin and actin. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jun 2010]

Chromosome

2

Cytoband

p13.3

Chromosome location (bp)

70607618 - 70768225

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000075340 (version 78.38)

Entrez gene

119

UniProt

P35612 (UniProt - Evidence at protein level)

neXtProt

NX_P35612

Antibodypedia

ADD2 antibodies
 

PROTEIN VIEW

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ADD2-001
 
ADD2-002
 
ADD2-005
 
ADD2-006
 
ADD2-008
 
ADD2-009
 
ADD2-010
 
ADD2-012
 
ADD2-014
 
ADD2-016
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ADD2-001 ENSP00000264436
ENST00000264436
P35612
Show all »
Show » Show » 726 80.9 No 0
ADD2-002 ENSP00000347972
ENST00000355733
P35612
Show all »
Show » Show » 643 72.7 No 0
ADD2-005 ENSP00000388072
ENST00000413157
P35612
Show all »
Show » Show » 559 62.5 No 0
ADD2-006 ENSP00000398112
ENST00000430656
P35612
Show all »
Show » Show » 575 64.2 No 0
ADD2-008 ENSP00000384677
ENST00000407644
P35612
Show all »
Show » Show » 726 80.9 No 0
ADD2-009 ENSP00000414546
ENST00000456320
C9JTM0
Show all »
Show » Show » 332 37.4 No 0
ADD2-010 ENSP00000412681
ENST00000425976
C9J299
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Show » Show » 143 16.4 No 0
ADD2-012 ENSP00000403722
ENST00000447731
Show » 17 1.7 No 0
ADD2-014 ENSP00000412357
ENST00000415348
C9J080
Show all »
Show » Show » 226 25.4 No 0
ADD2-016 ENSP00000430243
ENST00000522886
P35612
Show all »
Show » Show » 280 31.9 No 0