PICALM

GENERAL INFORMATION

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Gene name

PICALM

Gene description

Phosphatidylinositol binding clathrin assembly protein

Protein class

Cancer-related genes
Disease related genes
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

14
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Ubiquitous cytoplasmic and membranous expression, most abundant in gastrointestinal tract, kidney and placenta.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Supportive based on 2 antibodies.
HPA019053 , HPA019061
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Pancreas

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

PICALM (HGNC Symbol)

Synonyms

CALM, CLTH

Description

Phosphatidylinositol binding clathrin assembly protein (HGNC Symbol)

Entrez gene summary

This gene encodes a clathrin assembly protein, which recruits clathrin and adaptor protein complex 2 (AP2) to cell membranes at sites of coated-pit formation and clathrin-vesicle assembly. The protein may be required to determine the amount of membrane to be recycled, possibly by regulating the size of the clathrin cage. The protein is involved in AP2-dependent clathrin-mediated endocytosis at the neuromuscular junction. A chromosomal translocation t(10;11)(p13;q14) leading to the fusion of this gene and the MLLT10 gene is found in acute lymphoblastic leukemia, acute myeloid leukemia and malignant lymphomas. The polymorphisms of this gene are associated with the risk of Alzheimer disease. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011]

Chromosome

11

Cytoband

q14.2

Chromosome location (bp)

85957684 - 86069882

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000073921 (version 78.38)

Entrez gene

8301

UniProt

Q13492 (UniProt - Evidence at protein level)

neXtProt

NX_Q13492

Antibodypedia

PICALM antibodies


PROTEIN BROWSER

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ENST00000356360
 
ENST00000393346
 
ENST00000525162
 
ENST00000526033
 
ENST00000526961
 
ENST00000528256
 
ENST00000528398
 
ENST00000529016
 
ENST00000529760
 
ENST00000530542
 
ENST00000530692
 
ENST00000531930
 
ENST00000532317
 
ENST00000532603
 
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PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PICALM-001 ENSP00000433846
ENST00000526033
Q13492
Show all »
Show » Show » 645 70 No 0
PICALM-002 ENSP00000436958
ENST00000532317
Q13492
Show all »
Show » Show » 610 66.4 No 0
PICALM-003 ENSP00000434884
ENST00000528398
Q13492
Show all »
Show » Show » 551 59.9 No 0
PICALM-005 ENSP00000377015
ENST00000393346
Q13492
Show all »
Show » Show » 652 70.8 No 0
PICALM-006 ENSP00000348718
ENST00000356360
Q13492
Show all »
Show » Show » 632 68.8 No 0
PICALM-007 ENSP00000433303
ENST00000531930
E9PLJ8
Show all »
Show » Show » 185 21.3 No 0
PICALM-008 ENSP00000436508
ENST00000525162
E9PI56
Show all »
Show » Show » 148 17 No 0
PICALM-010 ENSP00000431545
ENST00000528256
E9PKP6
Show all »
Show » Show » 148 17.3 No 0
PICALM-017 ENSP00000435737
ENST00000530542
Show » 302 31.4 No 0
PICALM-018 ENSP00000435807
ENST00000529760
B4DLM1
Show all »
Show » 308 32.1 No 0
PICALM-019 ENSP00000432976
ENST00000526961
Show » 264 27.7 No 0
PICALM-020 ENSP00000435311
ENST00000532603
Show » 134 13.9 No 0
PICALM-021 ENSP00000436852
ENST00000530692
Show » 215 22.3 No 0
PICALM-023 ENSP00000432509
ENST00000529016
Show » 244 25.4 No 0