TBX21

GENE INFORMATION

? »

Gene name

TBX21 (HGNC Symbol)

Synonyms

T-bet, TBLYM

Description

T-box 21 (HGNC Symbol)

Entrez gene summary

This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene is the human ortholog of mouse Tbx21/Tbet gene. Studies in mouse show that Tbx21 protein is a Th1 cell-specific transcription factor that controls the expression of the hallmark Th1 cytokine, interferon-gamma (IFNG). Expression of the human ortholog also correlates with IFNG expression in Th1 and natural killer cells, suggesting a role for this gene in initiating Th1 lineage development from naive Th precursor cells. [provided by RefSeq, Jul 2008]

Chromosome

17

Cytoband

q21.32

Chromosome location (bp)

47733244 - 47746119

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000073861 (version 78.38)

Entrez gene

30009

UniProt

Q9UL17 (UniProt - Evidence at protein level)

neXtProt

NX_Q9UL17

Antibodypedia

TBX21 antibodies
 

PROTEIN VIEW

? »
 
 
 
TBX21-001
 
 
 
 
 

PROTEIN INFORMATION

? »

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

TBX21-001 ENSP00000177694
ENST00000177694
Q9UL17
Show all »
Show » Show » 535 58.3 No 0