FBXW11

GENE INFORMATION

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Gene name

FBXW11 (HGNC Symbol)

Synonyms

BTRC2, BTRCP2, Fbw11, Fbw1b, FBXW1B, Hos, KIAA0696

Description

F-box and WD repeat domain containing 11 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbws class and, in addition to an F-box, contains multiple WD40 repeats. This gene contains at least 14 exons, and its alternative splicing generates 3 transcript variants diverging at the presence/absence of two alternate exons. [provided by RefSeq, Jul 2008]

Chromosome

5

Cytoband

q35.1

Chromosome location (bp)

171861549 - 172006873

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000072803 (version 78.38)

Entrez gene

23291

UniProt

Q9UKB1 (UniProt - Evidence at protein level)

neXtProt

NX_Q9UKB1

Antibodypedia

FBXW11 antibodies
 

PROTEIN VIEW

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FBXW11-001
 
FBXW11-002
 
FBXW11-003
 
FBXW11-007
 
FBXW11-008
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

FBXW11-001 ENSP00000296933
ENST00000296933
Q9UKB1
Show all »
Show » Show » 529 60.9 No 0
FBXW11-002 ENSP00000265094
ENST00000265094
Q9UKB1
Show all »
Show » Show » 542 62.1 No 0
FBXW11-003 ENSP00000377391
ENST00000393802
Q9UKB1
Show all »
Show » Show » 508 58.4 No 0
FBXW11-007 ENSP00000428753
ENST00000517395
E5RGC1
Show all »
Show » Show » 197 22.7 No 0
FBXW11-008 ENSP00000429818
ENST00000518752
E5RH92
Show all »
Show » 74 8.6 No 0