UBE2D1

GENERAL INFORMATION

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Gene name

UBE2D1

Gene description

Ubiquitin-conjugating enzyme E2D 1

Protein class

Enzymes
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

2
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Most normal cells showed weak to moderate nuclear membrane positivity with additional cytoplasmic immunoreactivity.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Uncertain based on 1 antibody.
HPA003920
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

UBE2D1 (HGNC Symbol)

Synonyms

E2(17)KB1, SFT, UBC4/5, UBCH5, UbcH5A

Description

Ubiquitin-conjugating enzyme E2D 1 (HGNC Symbol)

Entrez gene summary

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is closely related to a stimulator of iron transport (SFT), and is up-regulated in hereditary hemochromatosis. It also functions in the ubiquitination of the tumor-suppressor protein p53 and the hypoxia-inducible transcription factor HIF1alpha by interacting with the E1 ubiquitin-activating enzyme and the E3 ubiquitin-protein ligases. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2011]

Chromosome

10

Cytoband

q21.1

Chromosome location (bp)

58334975 - 58370753

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000072401 (version 78.38)

Entrez gene

7321

UniProt

P51668 (UniProt - Evidence at protein level)

neXtProt

NX_P51668

Antibodypedia

UBE2D1 antibodies


PROTEIN BROWSER

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ENST00000373910
 
ENST00000615793
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

UBE2D1-001 ENSP00000363019
ENST00000373910
P51668
Show all »
Show » Show » 147 16.6 No 0
UBE2D1-201 ENSP00000479814
ENST00000615793
Show » 109 12.4 No 0