Tissue expression of TCF3 - Summary - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. Don't show this again.

TCF3

TISSUE

SUBCELL

CELL LINE

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN ANTIBODY/ANTIGEN


Dictionary

GENERAL INFORMATION ? »
Protein class Protein class the gene product belongs to according to selected gene lists. List of protein classes. Predicted localization Protein localization predicted from several bioinformatic algorithms. More info... Number of transcripts Number of protein-coding transcribed from this gene as defined by Ensembl.
Gene name	TCF3
Gene description	Transcription factor 3
Protein class	Cancer-related genes Disease related genes Plasma proteins Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	15
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

? »

RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Nuclear expression in most tissues.

ANTIBODY RELIABILITY ? »
Data reliability description Standardized explanatory sentences with additional information required for full understanding of the knowledge-based expression profile. Currently, not all genes have been analyzed by knowledge-based annotation, indicated by "Pending RNA-based expert annotation", when applicable. Data reliability Data reliability score (score description), divided into supportive (premium) or uncertain (not premium), is based on consistency between the staining pattern of one antibody or several antibodies with RNA-seq data and available gene/protein characterization data.
Data reliability description	Pending RNA-based expert annotation.
Data reliability	Supportive based on 3 antibodies. HPA049808 , HPA062476 , CAB018351
	SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

? »

RNA expression (FPKM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Lateral ventricle

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

N/A

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

N/A

Prostate

Seminal vesicle

N/A

Female tissues

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

PROTEIN EXPRESSION OVERVIEW

? »

Organ

Expression

RNA EXPRESSION OVERVIEW

? »

HPA dataset

RNA tissue category:

Expressed in all

Organ

Expression

GTEx dataset

RNA tissue category:

Expressed in all

Organ

Expression

GENE INFORMATION ? »
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Gene name	TCF3 (HGNC Symbol)
Synonyms	bHLHb21, E2A, E47, ITF1, MGC129647, MGC129648, VDIR
Description	Transcription factor 3 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the E protein (class I) family of helix-loop-helix transcription factors. E proteins activate transcription by binding to regulatory E-box sequences on target genes as heterodimers or homodimers, and are inhibited by heterodimerization with inhibitor of DNA-binding (class IV) helix-loop-helix proteins. E proteins play a critical role in lymphopoiesis, and the encoded protein is required for B and T lymphocyte development. Deletion of this gene or diminished activity of the encoded protein may play a role in lymphoid malignancies. This gene is also involved in several chromosomal translocations that are associated with lymphoid malignancies including pre-B-cell acute lymphoblastic leukemia (t(1;19), with PBX1), childhood leukemia (t(19;19), with TFPT) and acute leukemia (t(12;19), with ZNF384). Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the short arm of chromosome 9. [provided by RefSeq, Sep 2011]
Chromosome	19
Cytoband	p13.3
Chromosome location (bp)	1609290 - 1652605
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000071564 (version 78.38)
Entrez gene	6929
UniProt	P15923 (UniProt - Evidence at protein level)
neXtProt	NX_P15923
Antibodypedia	TCF3 antibodies

PROTEIN BROWSER

? »

ENST00000262965		ENST00000344749		ENST00000395423		ENST00000453954		ENST00000585731		ENST00000586318		ENST00000586410		ENST00000587235		ENST00000587425		ENST00000588136		ENST00000590436		ENST00000590684		ENST00000592628		ENST00000593064		ENST00000611869

PROTEIN INFORMATION

? »

Splice variant	Ensembl	UniProt	Protein class	Gene ontology	Length (aa)	Molecular mass (kDa)	Signal peptide (predicted)
TCF3-001	ENSP00000480564 ENST00000611869	P15923 Show all » « Hide P15923 [Direct mapping] Transcription factor E2-alpha Q6PJU3 [Target identity:90%; Query identity:100%] TCF3 protein {ECO:0000313\|EMBL:AAH11665.1} K7EKB9 [Target identity:27%; Query identity:100%] Transcription factor E2-alpha {ECO:0000313\|Ensembl:ENSP00000465549} K7EPS2 [Target identity:24%; Query identity:100%] Transcription factor E2-alpha {ECO:0000313\|Ensembl:ENSP00000467508} K7ENI0 [Target identity:14%; Query identity:100%] Transcription factor E2-alpha {ECO:0000313\|Ensembl:ENSP00000466954} B1NYC3 [Target identity:3%; Query identity:100%] E2A-NMP4 fusion protein {ECO:0000313\|EMBL:ACB05872.1}	Show » « Hide Predicted intracellular proteins Plasma proteins Transcription factors Basic domains Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000790 [nuclear chromatin] GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0001078 [RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription] GO:0002326 [B cell lineage commitment] GO:0003677 [DNA binding] GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0003713 [transcription coactivator activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005667 [transcription factor complex] GO:0005737 [cytoplasm] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0008134 [transcription factor binding] GO:0030183 [B cell differentiation] GO:0030890 [positive regulation of B cell proliferation] GO:0031435 [mitogen-activated protein kinase kinase kinase binding] GO:0033152 [immunoglobulin V(D)J recombination] GO:0035326 [enhancer binding] GO:0042692 [muscle cell differentiation] GO:0042803 [protein homodimerization activity] GO:0043234 [protein complex] GO:0043425 [bHLH transcription factor binding] GO:0043565 [sequence-specific DNA binding] GO:0044212 [transcription regulatory region DNA binding] GO:0045666 [positive regulation of neuron differentiation] GO:0045787 [positive regulation of cell cycle] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046982 [protein heterodimerization activity] GO:0046983 [protein dimerization activity] GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity] GO:0051149 [positive regulation of muscle cell differentiation] GO:0070491 [repressing transcription factor binding] GO:0070644 [vitamin D response element binding] GO:0070888 [E-box binding] GO:2000045 [regulation of G1/S transition of mitotic cell cycle]	654	67.6	No
TCF3-002	ENSP00000468487 ENST00000588136	P15923 Show all » « Hide P15923 [Direct mapping] Transcription factor E2-alpha K7ENI0 [Target identity:14%; Query identity:100%] Transcription factor E2-alpha {ECO:0000313\|Ensembl:ENSP00000466954} B1NYC3 [Target identity:3%; Query identity:100%] E2A-NMP4 fusion protein {ECO:0000313\|EMBL:ACB05872.1}	Show » « Hide Predicted intracellular proteins Plasma proteins Transcription factors Basic domains Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000790 [nuclear chromatin] GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0001078 [RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription] GO:0002326 [B cell lineage commitment] GO:0003677 [DNA binding] GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0003713 [transcription coactivator activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005667 [transcription factor complex] GO:0005737 [cytoplasm] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0008134 [transcription factor binding] GO:0030183 [B cell differentiation] GO:0030890 [positive regulation of B cell proliferation] GO:0031435 [mitogen-activated protein kinase kinase kinase binding] GO:0033152 [immunoglobulin V(D)J recombination] GO:0035326 [enhancer binding] GO:0042692 [muscle cell differentiation] GO:0042803 [protein homodimerization activity] GO:0043234 [protein complex] GO:0043425 [bHLH transcription factor binding] GO:0043565 [sequence-specific DNA binding] GO:0044212 [transcription regulatory region DNA binding] GO:0045666 [positive regulation of neuron differentiation] GO:0045787 [positive regulation of cell cycle] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046982 [protein heterodimerization activity] GO:0046983 [protein dimerization activity] GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity] GO:0051149 [positive regulation of muscle cell differentiation] GO:0070491 [repressing transcription factor binding] GO:0070644 [vitamin D response element binding] GO:0070888 [E-box binding] GO:2000045 [regulation of G1/S transition of mitotic cell cycle]	651	67.3	No
TCF3-003	ENSP00000378813 ENST00000395423	Q2TB39 Show all » « Hide Q2TB39 [Target identity:100%; Query identity:100%] TCF3 protein {ECO:0000313\|EMBL:AAI10581.1}; Transcription factor E2-alpha {ECO:0000313\|Ensembl:ENSP00000378813} B1NYC3 [Target identity:3%; Query identity:100%] E2A-NMP4 fusion protein {ECO:0000313\|EMBL:ACB05872.1}	Show » « Hide MEMSAT-SVM predicted membrane proteins Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0046983 [protein dimerization activity]	658	68.5	No
TCF3-004	ENSP00000466565 ENST00000590684		Show » « Hide Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0046983 [protein dimerization activity]	220	24	No
TCF3-005	ENSP00000465510 ENST00000585731	K7EMM4 Show all » « Hide K7EMM4 [Target identity:100%; Query identity:100%] Transcription factor E2-alpha {ECO:0000313\|Ensembl:ENSP00000466565}	Show » « Hide Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0046983 [protein dimerization activity]	159	18.1	No
TCF3-006	ENSP00000465549 ENST00000592628	K7EKB9 Show all » « Hide K7EKB9 [Target identity:100%; Query identity:100%] Transcription factor E2-alpha {ECO:0000313\|Ensembl:ENSP00000465549} K7EPS2 [Target identity:91%; Query identity:100%] Transcription factor E2-alpha {ECO:0000313\|Ensembl:ENSP00000467508}	Show » « Hide Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0046983 [protein dimerization activity]	179	20.1	No
TCF3-007	ENSP00000466954 ENST00000586318	K7ENI0 Show all » « Hide K7ENI0 [Target identity:100%; Query identity:100%] Transcription factor E2-alpha {ECO:0000313\|Ensembl:ENSP00000466954}	Show » « Hide Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)		95	10	No
TCF3-008	ENSP00000396363 ENST00000453954	K7ELF3 Show all » « Hide K7ELF3 [Target identity:31%; Query identity:100%] Transcription factor E2-alpha {ECO:0000313\|Ensembl:ENSP00000466052} K7EMM4 [Target identity:23%; Query identity:100%] Transcription factor E2-alpha {ECO:0000313\|Ensembl:ENSP00000466565} K7ENI0 [Target identity:13%; Query identity:100%] Transcription factor E2-alpha {ECO:0000313\|Ensembl:ENSP00000466954} B1NYC3 [Target identity:3%; Query identity:100%] E2A-NMP4 fusion protein {ECO:0000313\|EMBL:ACB05872.1}	Show » « Hide Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0046983 [protein dimerization activity]	679	70.1	No
TCF3-009	ENSP00000466952 ENST00000590436		Show » « Hide SCAMPI predicted membrane proteins Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0046983 [protein dimerization activity]	314	33.5	No
TCF3-013	ENSP00000467508 ENST00000587425	K7EPS2 Show all » « Hide K7EPS2 [Target identity:98%; Query identity:100%] Transcription factor E2-alpha {ECO:0000313\|Ensembl:ENSP00000467508}	Show » « Hide Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0046983 [protein dimerization activity]	165	18.7	No
TCF3-014	ENSP00000468481 ENST00000593064	K7EKB9 Show all » « Hide K7EKB9 [Target identity:87%; Query identity:100%] Transcription factor E2-alpha {ECO:0000313\|Ensembl:ENSP00000465549} K7EPS2 [Target identity:79%; Query identity:100%] Transcription factor E2-alpha {ECO:0000313\|Ensembl:ENSP00000467508}	Show » « Hide Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0046983 [protein dimerization activity]	204	22.5	No
TCF3-016	ENSP00000467388 ENST00000586410		Show » « Hide Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)		96	9.6	No
TCF3-017	ENSP00000466052 ENST00000587235	K7ENI0 Show all » « Hide K7ENI0 [Target identity:44%; Query identity:100%] Transcription factor E2-alpha {ECO:0000313\|Ensembl:ENSP00000466954}	Show » « Hide Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)		213	21.9	No
TCF3-201	ENSP00000262965 ENST00000262965	P15923 Show all » « Hide P15923 [Direct mapping] Transcription factor E2-alpha Q6PJU3 [Target identity:90%; Query identity:100%] TCF3 protein {ECO:0000313\|EMBL:AAH11665.1} K7EKB9 [Target identity:27%; Query identity:100%] Transcription factor E2-alpha {ECO:0000313\|Ensembl:ENSP00000465549} K7EPS2 [Target identity:24%; Query identity:100%] Transcription factor E2-alpha {ECO:0000313\|Ensembl:ENSP00000467508} K7ENI0 [Target identity:14%; Query identity:100%] Transcription factor E2-alpha {ECO:0000313\|Ensembl:ENSP00000466954} B1NYC3 [Target identity:3%; Query identity:100%] E2A-NMP4 fusion protein {ECO:0000313\|EMBL:ACB05872.1}	Show » « Hide Predicted intracellular proteins Plasma proteins Transcription factors Basic domains Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000788 [nuclear nucleosome] GO:0000790 [nuclear chromatin] GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0001078 [RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription] GO:0001779 [natural killer cell differentiation] GO:0002326 [B cell lineage commitment] GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0003713 [transcription coactivator activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005667 [transcription factor complex] GO:0005737 [cytoplasm] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0008134 [transcription factor binding] GO:0010628 [positive regulation of gene expression] GO:0030098 [lymphocyte differentiation] GO:0030183 [B cell differentiation] GO:0030890 [positive regulation of B cell proliferation] GO:0031435 [mitogen-activated protein kinase kinase kinase binding] GO:0032496 [response to lipopolysaccharide] GO:0033077 [T cell differentiation in thymus] GO:0033152 [immunoglobulin V(D)J recombination] GO:0035326 [enhancer binding] GO:0042493 [response to drug] GO:0042692 [muscle cell differentiation] GO:0042803 [protein homodimerization activity] GO:0043234 [protein complex] GO:0043425 [bHLH transcription factor binding] GO:0043565 [sequence-specific DNA binding] GO:0043966 [histone H3 acetylation] GO:0043967 [histone H4 acetylation] GO:0044212 [transcription regulatory region DNA binding] GO:0045666 [positive regulation of neuron differentiation] GO:0045787 [positive regulation of cell cycle] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046982 [protein heterodimerization activity] GO:0046983 [protein dimerization activity] GO:0048468 [cell development] GO:0048541 [Peyer's patch development] GO:0050821 [protein stabilization] GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity] GO:0051149 [positive regulation of muscle cell differentiation] GO:0070491 [repressing transcription factor binding] GO:0070644 [vitamin D response element binding] GO:0070888 [E-box binding] GO:2000045 [regulation of G1/S transition of mitotic cell cycle]	654	67.6	No
TCF3-202	ENSP00000344375 ENST00000344749	B1NYC3 Show all » « Hide B1NYC3 [Target identity:3%; Query identity:100%] E2A-NMP4 fusion protein {ECO:0000313\|EMBL:ACB05872.1}	Show » « Hide Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0046983 [protein dimerization activity]	600	62	No

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.

Protein class

Predicted localization

Number of transcripts

RNA tissue category

Protein evidence

Protein localization

Data reliability description

Data reliability

RNA expression (FPKM)

Protein expression (score)

HPA dataset

RNA tissue category HPA

GTEx dataset

RNA tissue category GTEx