RAD18

GENE INFORMATION

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Gene name

RAD18 (HGNC Symbol)

Synonyms

RNF73

Description

RAD18 E3 ubiquitin protein ligase (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is highly similar to S. cerevisiae DNA damage repair protein Rad18. Yeast Rad18 functions through its interaction with Rad6, which is an ubiquitin-conjugating enzyme required for post-replication repair of damaged DNA. Similar to its yeast counterpart, this protein is able to interact with the human homolog of yeast Rad6 protein through a conserved ring-finger motif. Mutation of this motif results in defective replication of UV-damaged DNA and hypersensitivity to multiple mutagens. [provided by RefSeq, Jul 2008]

Chromosome

3

Cytoband

p25.3

Chromosome location (bp)

8775402 - 8963773

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000070950 (version 78.38)

Entrez gene

56852

UniProt

Q9NS91 (UniProt - Evidence at protein level)

neXtProt

NX_Q9NS91

Antibodypedia

RAD18 antibodies
 

PROTEIN VIEW

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RAD18-001
 
RAD18-003
 
RAD18-007
 
RAD18-008
 
RAD18-009
 
RAD18-010
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

RAD18-001 ENSP00000264926
ENST00000264926
Q9NS91
Show all »
Show » Show » 495 56.2 No 0
RAD18-003 ENSP00000393783
ENST00000429790
H7C0A5
Show all »
Show » 79 8.8 No 0
RAD18-007 ENSP00000412261
ENST00000413832
C9J0Q4
Show all »
Show » Show » 92 10.6 No 0
RAD18-008 ENSP00000412054
ENST00000427329
H7C0A5
Show all »
Show » 131 14.7 No 0
RAD18-009 ENSP00000399620
ENST00000421052
F8WFA6
Show all »
Show » Show » 126 14.2 No 0
RAD18-010 ENSP00000397852
ENST00000418463
F8WAZ7
Show all »
Show » 53 6 No 0