TFE3

GENE INFORMATION

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Gene name

TFE3 (HGNC Symbol)

Synonyms

bHLHe33, TFEA

Description

Transcription factor binding to IGHM enhancer 3 (HGNC Symbol)

Entrez gene summary

This gene encodes a basic helix-loop-helix domain-containing transcription factor that binds MUE3-type E-box sequences in the promoter of genes. The encoded protein promotes the expression of genes downstream of transforming growth factor beta (TGF-beta) signaling. This gene may be involved in chromosomal translocations in renal cell carcinomas and other cancers, resulting in the production of fusion proteins. Translocation partners include PRCC (papillary renal cell carcinoma), NONO (non-POU domain containing, octamer-binding), and ASPSCR1 (alveolar soft part sarcoma chromosome region, candidate 1), among other genes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

Chromosome

X

Cytoband

p11.23

Chromosome location (bp)

49028726 - 49043486

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000068323 (version 78.38)

Entrez gene

7030

UniProt

P19532 (UniProt - Evidence at protein level)

neXtProt

NX_P19532

Antibodypedia

TFE3 antibodies
 

PROTEIN VIEW

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TFE3-001
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

TFE3-001 ENSP00000314129
ENST00000315869
P19532
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